Phase II Study of Oral Nafithromycin in CABP

Inclusion Criteria:

Meet the clinical criteria for CABP based on following:

1. Clinical symptoms (new or worsening)

2. Vital sign abnormalities

3. Laboratory abnormalities

4. Radiographic evidence of CABP

5. PORT score

Exclusion Criteria:

1. Subjects with any of the following confirmed or suspected types of pneumonia:

1. Aspiration pneumonia

2. Hospital-acquired bacterial pneumonia (HABP)

3. Healthcare-associated bacterial pneumonia (HCAP)

4. Ventilator-associated bacterial pneumonia (VABP)

5. Pneumonia that may be caused by pathogen(s) resistant to either study drug

2. Receipt of 1 or more dose(s) of a potentially effective systemic antibacterial
treatment for treatment of the current CABP

3. Suspected or confirmed non-infectious causes of pulmonary infiltrates

4. Subjects requiring concomitant adjunctive or additional potentially-effective systemic
antibacterial treatment for management of CABP