Neomycin and Metronidazole Hydrochloride With or Without Polyethylene Glycol in Reducing Infection in Patients Undergoing Elective Colorectal Surgery
| Status: | Recruiting |
|---|---|
| Conditions: | Colorectal Cancer, Irritable Bowel Syndrome (IBS), Infectious Disease, Hospital, Gastrointestinal, Gastrointestinal, Diverticulitis |
| Therapuetic Areas: | Gastroenterology, Immunology / Infectious Diseases, Oncology, Other |
| Healthy: | No |
| Age Range: | 19 - Any |
| Updated: | 8/24/2018 |
| Start Date: | September 2016 |
| End Date: | October 2021 |
| Contact: | Benjamin Phillips, MD |
| Phone: | (215) 551-0360 |
Combined Mechanical and Oral Antibiotic Bowel Preparation Versus Oral Antibiotics Alone for the Reduction of Surgical Site Infection Following Elective Colorectal Resection
This randomized clinical trial studies how well neomycin and metronidazole hydrochloride with
or without polyethylene glycol work in reducing infection in patients undergoing elective
colorectal surgery. Polyethylene glycol, may draw water from the body into the colon,
flushing out the contents of the colon. Antibiotics, like neomycin and metronidazole
hydrochloride, may stop bacteria from growing. It is not yet known whether it's better to
give preoperative neomycin and metronidazole hydrochloride with or without polyethylene
glycol in reducing surgical site infection after colorectal surgery.
or without polyethylene glycol work in reducing infection in patients undergoing elective
colorectal surgery. Polyethylene glycol, may draw water from the body into the colon,
flushing out the contents of the colon. Antibiotics, like neomycin and metronidazole
hydrochloride, may stop bacteria from growing. It is not yet known whether it's better to
give preoperative neomycin and metronidazole hydrochloride with or without polyethylene
glycol in reducing surgical site infection after colorectal surgery.
PRIMARY OBJECTIVES:
I. To estimate the difference in rates of surgical site infection following elective
colorectal resections in patients given a preoperative mechanical bowel prep with oral
antibiotics as compared to preoperative oral antibiotics alone.
SECONDARY OBJECTIVES:
I. To determine rates of post-operative clostridium difficile infection, adynamic ileus,
cardiopulmonary complications, urinary tract infection, length of stay and mortality in
patients given preoperative oral antibiotics with a mechanical bowel prep versus preoperative
antibiotics alone.
I. To estimate the difference in rates of surgical site infection following elective
colorectal resections in patients given a preoperative mechanical bowel prep with oral
antibiotics as compared to preoperative oral antibiotics alone.
SECONDARY OBJECTIVES:
I. To determine rates of post-operative clostridium difficile infection, adynamic ileus,
cardiopulmonary complications, urinary tract infection, length of stay and mortality in
patients given preoperative oral antibiotics with a mechanical bowel prep versus preoperative
antibiotics alone.
Inclusion Criteria:
- Patients undergoing ileocolic resections, partial and total colectomies, and rectal
resections for neoplasm, inflammatory bowel disease, or diverticulitis
- Subjects with the mental capacity to give informed consent
Exclusion Criteria:
- Patients undergoing emergent colorectal resections
- Patients who are decisionally-impaired and lack the mental capacity to give informed
consent
We found this trial at
1
site
1020 Walnut St
Philadelphia, Pennsylvania 19107
Philadelphia, Pennsylvania 19107
(215) 955-6000
Phone: 215-551-0360
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