Platelet-rich Plasma vs. Hyaluronic Acid for Glenohumeral Osteoarthritis

Glenohumeral OA accounts for approximately 2-5% of all chronic shoulder pain and may be
classified into primary and secondary forms. Primary glenohumeral OA is caused by
degenerative joint disease, inflammatory arthropathies, and neuropathic arthropathy secondary
to syringomyelia or diabetes. Secondary glenohumeral OA is caused by trauma, postoperative
changes after arthroscopy or capulorraphy, and osteonecrosis. Hyaluronic acid is found in
synovial joint fluid and has viscoelastic, chondroprotective, and possibly anti-inflammatory
properties. It has been shown to increase joint lubrication. Platelet-rich plasma contains
growth factors that have been shown to promote tissue regeneration. The aim of this study is
to determine whether injections of hyaluronic acid or platelet-rich plasma can be used
reliably to decrease pain, restore function, and improve quality of life in patients
suffering from glenohumeral OA. Patients will be randomized to receive either an injection of
hyaluronic acid or an injection of platelet-rich plasma. Outcomes will be assessed via
questionnaires for up to 52 weeks post-procedure.

Inclusion Criteria:

- English speaking/literate

- Age 18-100 years

- Visual analog score pain >= 5

- Greater than or equal to 3 months of pain after onset of symptoms that has failed
conservative treatments

- Confirmation of glenohumeral OA via routine imaging (MRI and x-ray; must be recent and
within the past year)

- Transient relief of symptoms after diagnostic intra-articular injection into the
glenohumeral joint

Exclusion Criteria:

- Non-English speaking/illiterate

- Painful active, concurrent cervical spine conditions

- Current non-steroidal anti-inflammatory drug (NSAID) use

- History of taking coumadin or similar anticoagulant, have a known coagulopathy,
bleeding dyscrasia, or platelet count < 150,000/cubic mm

- Allergic reaction to poultry or previous viscosupplementation

- Involved in workers' compensation or active litigation involving affected shoulder

- Inability to refrain from NSAID use for 5 days prior to and 6 weeks after injection

- History of corticosteroid injection to affected shoulder within the last 3 months

- History of viscosupplementation or platelet-rich plasma to affected shoulder within
the last 6 months

- Presence of acute fracture

- History of shoulder tumor

- Known uncontrolled systemic illness (uncontrolled diabetes, human immunodeficiency
virus, vasculitis, autoimmune/inflammatory disease)

- Psychiatric and somatoform disorders