COLLAGEN CROSS-LINKING WITH ULTRAVIOLET-A IN ASYMMETRIC CORNEAS

This study will evaluate the results of Corneal Collagen Crosslinking (CXL) in patients with
conditions that include keratoconus, forme fruste keratoconus, post-LASIK ectasia, pellucid
marginal degeneration, forme fruste pellucid marginal degeneration, diurnal fluctuation
post-radial keratotomy, or Terrien's marginal degeneration. This is an outcomes study, all
patients receive treatment.

Inclusion Criteria:

- A diagnosis of at least one of the following conditions:

1. Keratoconus

2. Forme fruste keratoconus

3. Post-LASIK ectasia

4. Pellucid marginal degeneration

5. Forme fruste pellucid marginal degeneration

6. Diurnal fluctuation post-radial keratotomy

7. Terrien's marginal degeneration

Exclusion Criteria:

1. Corneal thickness < 375 microns measured by ultrasound or Pentacam.

2. Contraindications or hypersensitivities to any study medications or their components.

3. Pregnancy or breastfeeding.

4. Any history of herpes simplex corneal disease in an eye to be treated.

5. Nystagmus or any other condition that would, in the judgement of the investigator,
prevent a steady gaze during the treatment.

6. Inability to cooperate with diagnostic tests.

7. Enrollment in another ophthalmic clinical trial.