Chronic Hepatitis Intervention Project for Drug Users
| Status: | Completed |
|---|---|
| Conditions: | HIV / AIDS, Hepatitis, Hepatitis |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/2/2017 |
| Start Date: | September 2003 |
| End Date: | November 2006 |
The purpose of this study is to determine if a 6-session motivational interviewing
intervention is more effective than a 6-session educational intervention at reducing
behaviors that may lead to infection, transmission, and progression of HIV and hepatitis C
among out of treatment injecting drug users.
intervention is more effective than a 6-session educational intervention at reducing
behaviors that may lead to infection, transmission, and progression of HIV and hepatitis C
among out of treatment injecting drug users.
This 4.5-year community-based study is a randomized field experiment that uses a two-group
design. Participants are randomized into either an Educational intervention group or a
Motivational intervention group. We are comparing the effectiveness of the Motivational
intervention with the Educational intervention. We are also estimating the costs and
evaluating the cost-effectiveness of the Motivational intervention relative to the
Educational intervention.
We have the following aims and related hypotheses:
Aim 1: To compare the effectiveness of a 6-session personalized motivational intervention to
a 6-session educational intervention in terms of injection risk, sexual behavior, alcohol
use, and knowledge and perception related to HBV and HCV; H1. Relative to the Educational
intervention group, a greater proportion of the Motivational intervention group will report
no injection risk at 6- and 12-month follow-up interviews. No injection risk is
operationally defined as either no injections in the past 30 days, or no direct or indirect
sharing of syringes and other injection equipment in the past 30 days.
H2. Relative to the Educational intervention group, a greater proportion of the Motivational
intervention group will report no sexual risk at 6- and 12-month follow-up interviews. No
sexual risk is operationally defined as either no sex (oral, vaginal, or anal) in the past
30 days, or no unprotected oral, vaginal, or anal sex in the past 30 days.
H3. Relative to the Educational intervention group, the Motivational intervention group will
report greater decreases in frequency of alcohol consumption and quantity of alcohol
consumed. Frequency of alcohol consumption is defined as "number of days drank alcohol in
the past 30 days," and quantity of alcohol consumed is defined as "the average number of
drinks per drinking day during the past 30 days." H4. Relative to the Educational
intervention group, participants in the Motivational intervention group will report greater
increases in knowledge and more accurate perceptions of severity of disease and efficacy of
protective actions regarding hepatitis B and C at Session 3.
Aim 2: To estimate the cost and cost-effectiveness of a 6-session personalized motivational
intervention relative to a 6-session educational intervention.
H5. The Motivational Intervention will cost more than the Educational Intervention, but will
be cost-effective at eliminating injection risk behavior and sexual risk behavior and at
reducing alcohol use
design. Participants are randomized into either an Educational intervention group or a
Motivational intervention group. We are comparing the effectiveness of the Motivational
intervention with the Educational intervention. We are also estimating the costs and
evaluating the cost-effectiveness of the Motivational intervention relative to the
Educational intervention.
We have the following aims and related hypotheses:
Aim 1: To compare the effectiveness of a 6-session personalized motivational intervention to
a 6-session educational intervention in terms of injection risk, sexual behavior, alcohol
use, and knowledge and perception related to HBV and HCV; H1. Relative to the Educational
intervention group, a greater proportion of the Motivational intervention group will report
no injection risk at 6- and 12-month follow-up interviews. No injection risk is
operationally defined as either no injections in the past 30 days, or no direct or indirect
sharing of syringes and other injection equipment in the past 30 days.
H2. Relative to the Educational intervention group, a greater proportion of the Motivational
intervention group will report no sexual risk at 6- and 12-month follow-up interviews. No
sexual risk is operationally defined as either no sex (oral, vaginal, or anal) in the past
30 days, or no unprotected oral, vaginal, or anal sex in the past 30 days.
H3. Relative to the Educational intervention group, the Motivational intervention group will
report greater decreases in frequency of alcohol consumption and quantity of alcohol
consumed. Frequency of alcohol consumption is defined as "number of days drank alcohol in
the past 30 days," and quantity of alcohol consumed is defined as "the average number of
drinks per drinking day during the past 30 days." H4. Relative to the Educational
intervention group, participants in the Motivational intervention group will report greater
increases in knowledge and more accurate perceptions of severity of disease and efficacy of
protective actions regarding hepatitis B and C at Session 3.
Aim 2: To estimate the cost and cost-effectiveness of a 6-session personalized motivational
intervention relative to a 6-session educational intervention.
H5. The Motivational Intervention will cost more than the Educational Intervention, but will
be cost-effective at eliminating injection risk behavior and sexual risk behavior and at
reducing alcohol use
Inclusion Criteria:
- minimum age of 18 years injected illicit drugs within last 30 days
Exclusion Criteria:
- participated in formal substance treatment in last 30 days
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