Effect of Inhaled Insulin (AERx® iDMS) on Blood Glucose Control in Type 2 Diabetes



Status:Terminated
Conditions:Diabetes, Diabetes
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:9/7/2018
Start Date:November 29, 2006
End Date:March 18, 2008

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Effect of Inhaled Insulin (AERx® iDMS) Plus Pioglitazone Versus Pioglitazone Alone on HbA1c in Subjects With Type 2 Diabetes

This trial is conducted in the United States of America (USA). This trial will compare the
changes in HbA1c after 26 weeks of inhaled insulin and pioglitazone combination therapy
versus pioglitazone treatment alone.

The decision to discontinue the development of AERx® is not due to any safety concerns. An
analysis concluded that fast-acting inhaled insulin in the form it is known today, is
unlikely to offer significant clinical or convenience benefits over injections of modern
insulin with pen devices.

Inclusion Criteria:

- Type 2 diabetes

- Current treatment with oral antidiabetes drugs (OADs) for at least 2 months

- HbA1c between 7.0-11.0% if on OAD monotherapy

- HbA1c between 7.0-10.0% if on OAD combination therapy

- BMI less than or equal to 40 kg/m2

Exclusion Criteria:

- Current regular smoking or regular smoking within the last 6 months

- Current acute or chronic pulmonary disease (except for asthma)

- Proliferative retinopathy requiring treatment

- Clinically significant disease history including kidney or liver disease, or heart
disease which limits physical activity or results in discomfort with physical activity

- Pregnancy
We found this trial at
103
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Kingsport, Tennessee 37660
237
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from 43215
Kingsport, TN
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Altoona, Pennsylvania 16602
247
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Arlington, Texas 76012
928
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Arlington, Virginia 22206
324
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Arvada, Colorado 80005
1166
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Arvada, CO
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Athens, Georgia 30606
415
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Athens, GA
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Atlanta, Georgia 30318
436
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Atlanta, GA
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Avon, Illinois 46123
393
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Baltimore, Maryland 21229
340
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Beaver, Pennsylvania 15009
151
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Bensalem, Pennsylvania 19020
426
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Bermuda Dunes, California 92203
1876
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Beverly Hills, Florida 34465
764
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Billings, Montana 59101
1344
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Bismarck, North Dakota 58501
1006
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Bismarck, ND
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Bloomington, Minnesota 55420
622
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Blue Ridge, Georgia 30513
359
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Boca Raton, Florida 33433
955
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1711
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Boise, ID
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Canal Fulton, Ohio 44614
98
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Charlotte, North Carolina 28277
348
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Chesterfield, Missouri 63017
413
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Chicago, Illinois 60612
274
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Cincinnati, Ohio 45229
95
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Clarksville, Tennessee 37043
334
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Clearwater, Florida 33756
830
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Cleveland, Ohio 44106
126
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Clinton, Oklahoma 73601
922
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Colorado Springs, Colorado 80910
1161
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Dallas, Texas 75231
905
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65
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Dayton, OH
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Des Moines, Iowa 50314
565
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Des Moines, IA
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Dunwoody, Georgia 30338
422
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Escondido, California 92025
1936
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Fresno, California 93702
1988
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Greer, South Carolina 29651
350
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Hershey, Pennsylvania 17033
337
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Hialeah, Florida 33012
987
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High Point, North Carolina 27265
303
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Hollywood, Florida 33024
978
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Honolulu, Hawaii 96814
4501
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Houston, Texas 77030
995
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Huntington Beach, California 92648
1969
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Jackson, Mississippi 39209
662
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Jefferson City, Missouri 65109
498
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Kansas City, Missouri 64106
617
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La Jolla, California 92037
1954
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Lafayette, Indiana 47904
205
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Lake Mary, Florida 32746
780
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Las Vegas, Nevada 89128
1762
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Lewisville, Texas 75067
909
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Lexington, Kentucky 40503
157
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Little Rock, Arkansas 72202
623
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Marianna, Florida 32446
646
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Marlborough, Massachusetts 01752
618
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Medford, Oregon 97501
2060
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Melbourne, Florida 32901
832
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Miami, Florida 33136
992
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Niceville, Florida 32578
681
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Norfolk, Virginia 23510
423
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Norristown, Pennsylvania 19401
406
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Northridge, California 91325
1981
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Oklahoma City, Oklahoma 73112
849
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Orange, California 92868
1958
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Ozark, Alabama 36360
605
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Palm Harbor, Florida 34684
821
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Panama City, Florida 32401
693
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Pembroke Pines, Florida 33026
978
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Peoria, Illinois 61615
349
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898
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Plano, TX
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Poway, California 92064
1938
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Powder Springs, Georgia 30127
431
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Prince Frederick, Maryland 20678
358
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Raleigh, North Carolina 27610
375
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Richmond, Virginia 23219
342
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Roseville, California 95661
2028
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Roswell, Georgia 30076
414
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Sacramento, California 95821
2043
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Saint George, Utah 84790
1655
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Saint Louis, Missouri 63110
394
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Saint Petersburg, Florida 33713
842
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San Antonio, Texas 78224
1138
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San Diego, California 92111
1951
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Sandy Springs, Georgia 30328
424
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Santa Barbara, California 93105
2039
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Suwanee, Georgia 30024
412
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Syracuse, New York 13210
414
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Tacoma, Washington 98405
2012
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Tallahassee, Florida 32308
658
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Temecula, California 92591
1928
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Topeka, Kansas 66606
676
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Tucker, Georgia 30084
427
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Tucson, Arizona 85704
1638
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Tuscaloosa, Alabama 35406
530
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Tustin, California 92780
1957
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Vero Beach, Florida 32960
864
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Vestavia Hills, Alabama 35209
496
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Walnut Creek, California 94598
2084
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Waltham, Massachusetts 02453
633
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Warrenton, Virginia 20186
292
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West Palm Beach, Florida 33409
931
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