Assessment of Lung Movement With Computed Tomography (CT)

Interstitial lung disease (ILD) is a group of lung disorders in which the lung tissues become
inflamed and then damaged. Idiopathic Pulmonary Fibrosis (IPF) is one of the subtypes of ILD
which has characteristic histological and CT features. It is well known that microscopic
fibrosis occurs in the lungs of IPF patients well before the structural changes of fibrosis
become apparent on CT. By combining sophisticated image analysis with CT scans obtained at
full inspiration and full expiration, it may be possible to detect earlier changes of IPF
than currently possible by looking at macro structural features alone. With the recent
development of new therapeutics for IPF, early detection of the disease and improved
monitoring of treatment efficacy will become important. Using CT to assess regional lung
compliance has the potential to become an easily translated clinical tool.

Inclusion Criteria:

- Subjects with ILD: Subjects must have a physician diagnosis of ILD and be in stable
pulmonary condition at the time of the CT

- Healthy subjects: Subjects must have no history of pulmonary disease and smoked less
than 100 cigarettes in their lifetime

Exclusion Criteria:

- Subjects less than 18 years of age