MMRF Molecular Profiling Protocol

Inclusion Criteria:

1. Patients must have a diagnosis of multiple myeloma or related malignancy

2. Patients are undergoing standard of care bone marrow aspirates

3. Patients (male or female) from any race or ethnicity must be at least 18 years of age
at the time of registration.

4. Procedure-specific signed informed consent form prior to initiation of any
study-related procedures.

Exclusion Criteria:

1. It is the enrolling study physician's discretion to decide if a patient is not fit
enough to undergo a bone marrow aspirate.

2. Patients who are incarcerated are not eligible to participate.

3. Women who are pregnant

4. Patients who have had another malignancy within the last five (5) years (except for
basal or squamous cell carcinoma, or in situ cancer of the cervix) where there is a
possibility to contaminate the bone marrow aspirate.