Evaluate the Safety and Efficacy of 48-Hour Infusions of HNO (Nitroxyl) Donor in Hospitalized Patients With Heart Failure

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Actively being hospitalized for acute decompensated heart failure

- At least 1 administration of IV diuretic for the current episode

- Be randomized within 18 hours of first dose of IV diuretic for current episode for
Part 1 Cohort 1, or 48 hours for first dose for Part II Cohort II

- Have shortness of breath at rest or with minimal exertion after administration of 1
dose of IV diuretic

- Have history of heart failure and a left ventricular ejection fraction (LVEF) ≤ 40%

Exclusion Criteria:

- Systolic blood pressure <105mm Hg or >160mm Hg or heart rate <50 or >130 bpm

- Have an active infection requiring IV anti-microbial treatment

- Be hospitalized with acute coronary syndrome, coronary revascularization or acute
myocardial infarction during the previous 90 days prior to screening

- Have a history of a cerebral vascular accident (CVA or stroke) or of a transient
ischemic attack (TIA) during the previous 90 days prior to screening

- Suspected acute lung disease (e.g pneumonia or asthma) or severe chronic lung disease
(e.g. severe chronic obstructive pulmonary disease, or pulmonary fibrosis)

Other protocol defined inclusion/exclusion criteria could apply