A Multiple Dose Study to Assess the Safety and Tolerability of BMS-986166 in Healthy Volunteers

For more information regarding Bristol-Myers Squibb Clinical Trial participation, please
visit www.BMSStudyConnect.com

Inclusion Criteria:

- Healthy female patients of non-childbearing potential or male patients as determined
by medical history, physical examination, vital signs, 12-lead electrocardiogram
(ECG), and clinical laboratory evaluations will be eligible to participate in the
study

- Body Mass Index (BMI) of 18.0 to 32.0 kg/m2, inclusive

- This study permits the re-enrollment of a patient that has discontinued the study as a
pre-treatment failure (i.e. patient has not been randomized / has not been treated).
If re-enrolled, the patient must be re-consented

Exclusion Criteria:

- Women who are of childbearing potential, lactating or breastfeeding

- Any significant acute or chronic medical illness judged to be clinically significant
by the Investigator and/or Sponsor medical monitor

- Patients with history of any type of heart disease, including ischemia, infarction,
clinically significant arrhythmias, sinus syndrome, hypertension, symptomatic
orthostatic hypotension, atrioventricular block of any degree, bradycardia, syncope,
clinically significant ECG abnormalities, or any congenital heart disease

- Patients with any acute or chronic bacterial, fungal (except history of tinea pedis or
ongoing onychomycosis will not be exclusionary) or viral infection within the last 3
months prior to screening, as well as any febrile illness or viral infection within
the last 3 months prior to screening, as well as any febrile illness of unknown origin
within 14 days of screening

- Patients who have received any live vaccines within 1 month of study drug
administration, or who plan to have a live vaccine at any time during the study,
including during the follow up period

- Positive test for tuberculosis at screening

- Past or current history of neurologic disorders, Guillain-Barré Syndrome, central or
peripheral neuropathies, or past or current symptoms of sustained or recurrent
paresthesia's (tingling), numbness, or neuropathic pain (burning, aching or stabbing)
in any extremities

Other protocol defined inclusion/exclusion criteria could apply