Flortaucipir 18F PET Imaging in BIOCARD Study

Inclusion Criteria:

- Males or females that have provided consent and are currently enrolled in BIOCARD
study

- Ability to tolerate PET scan procedures

- Ability to provide informed consent for study procedures

Exclusion Criteria:

- Has condition(s) that could augment risk to participant or compromise ability to
tolerate experimental procedures or interfere with analysis of the study data as
determined by the investigator

- Has a history of risk factors for Torsades de Pointes or taking medications known to
cause QT prolongation.

- Has ECG acquired prior to initial 18F-AV-1451 scan that clinically contradicts
subject's participation in the study as determined by the investigator. Bazett's
corrected QT (QTcB) interval must be assessed and not exceed accepted values (458 msec
in males, 474 msec in females).

- Females of childbearing potential who are not surgically sterile, not refraining from
sexual activity, or not using reliable contraceptive methods.

- Has hypersensitivity to 18F-AV-1451.

- Has a currently clinically significant infectious disease, endocrine/metabolic
disease, pulmonary/renal/hepatic impairment, or cancer that could impact study
participation or scan results in the opinion of the investigator.

- Has a non-study related radiopharmaceutical imaging/treatment procedure within seven
days prior to 18F-AV-1451 imaging visit.

- Is unsuitable for a study of this type in the opinion of the investigator.