Comparison of MRI and CEDM to Evaluate Treatment Response Before Surgery

Inclusion Criteria:

- Any woman who has completed or is nearing completion of neoadjuvant therapy for breast
cancer and is scheduled for a post-NAT breast MRI and mammogram

- Surgery (mastectomy or BCT) planned within 60 days of the MRI

Exclusion Criteria:

- Women who have a contraindication to the intravenous use of iodinated contrast agent
(i.e., allergy to iodinated contrast or severely impaired renal function with a
creatinine level > 1.3 or eGFR ≥45)

- Known allergic reaction to gadolinium; patient may be eligible if the referring
physician determines that the MRI is medically necessary and if the patient is willing
to undergo pre-medication for contrast allergy

- Pregnant women

- Male patients

- Presence of non MR compatible metallic objects or metallic objects that, in the
opinion of the radiologist, would make MRI a contraindication

- Known or suspected renal impairment. Requirements for GFR prior to MRI as determined
by local site standard practice

- Women who have already had their standard of care post-NAT mammogram and/or breast MRI