PVI as a Parameter to Predict Fluid Responsiveness



Status:Recruiting
Healthy:No
Age Range:18 - Any
Updated:3/23/2019
Start Date:December 15, 2016
End Date:July 31, 2019
Contact:Neal Fleming, MD, PhD
Email:nwfleming@ucdavis.edu
Phone:916-734-5046

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Trial Summary
Trial Overview
Inclusion Criteria

Validation of PVI as a Parameter to Predict Fluid Responsiveness

This is a prospective, randomized, sequential data collection study to evaluate the ability
of pleth variability index (PVI) to predict fluid responsiveness in comparison with other
dynamic parameters including pulse pressure variation (PPV) and stroke volume variation
(SVV).

Patients will be randomized to a tidal volume of either 6 or 8 ml.kg-1 of ideal body weight,
with positive end-expiratory pressure set between 3 and 5 cmH20.

The finger sensor will be applied to patients in the OR, and hemodynamic measurements will be
collected from standard OR monitors.

Inclusion Criteria:

- 18 years of age or older

- Scheduled for elective surgery requiring general anesthesia and mechanical ventilation

- Arterial line and Swan-Ganz catheter placed as part of the scheduled surgical
procedure

Exclusion Criteria:

- Patients with surgeries at or around site of sensor placement

- Skin abnormalities affecting the sensor placement area

- Patients with cardiac arrhythmias

- Patients with intracardiac shunts
We found this trial at
1
site
UC Davis Health
2315 Stockton Blvd
Sacramento, California 95817
Principal Investigator: Neal W Fleming, M.D., Ph.D.
Phone: 916-734-5394
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mi
from
Sacramento, CA
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