Cardiac Resynchronization Therapy in Pulmonary Hypertension



Status:Completed
Conditions:High Blood Pressure (Hypertension), High Blood Pressure (Hypertension)
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - 75
Updated:9/21/2017
Start Date:November 29, 2012
End Date:March 23, 2017

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Trial Summary
Trial Overview
Inclusion Criteria
This study is being conducted to determine whether patients with advanced pulmonary
hypertension when treated with cardiac resynchronization therapy improve hemodynamically
and/or receive clinical benefit.

This study aims to determine whether stimulating earlier activation of the failing right
ventricle in pulmonary hypertension reduces the effects of interventricular dependence in
human subjects, thereby improving overall cardiac function and symptoms in patients with
pulmonary hypertension and right ventricle failure with NYHA Class 3-4 symptoms.

Inclusion Criteria:

- Pulmonary hypertension, defined as pulmonary artery systolic pressure greater than 40
mm Hg by transthoracic echocardiogram or right heart catheterization

- LVEF ≥ 50%

- Baseline 6MWT distant <400 meters

- Baseline NYHA Functional class ≥ III

Exclusion Criteria:

- LVEF < 50%

- 6MWT duration > 400 meters

- NYHA Functional class < III

- Left bundle branch block

- Non-sinus rhythm

- Severe aortic stenosis (Aortic valve area < 1 cm2)

- Severe mitral regurgitation

- Acute cardiac failure

- Dependency on intravenous inotropies

- Severe obstructive pulmonary disease

- Hypertrophic obstructive cardiomyopathy

- Amyloidosis

- Dependence on pacing
We found this trial at
1
site
Ochsner Medical Center
1514 Jefferson Hwy.
New Orleans, Louisiana 70121
504-842-3000
Principal Investigator: Daniel Morin, MD
Phone: 504-842-6729
Ochsner Medical Center Ochsner Medical Center is located near uptown New Orleans and includes acute...
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from
New Orleans, LA
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