COX-2 Inhibitor Study In Patients With Rheumatoid Arthritis



Status:Completed
Conditions:Arthritis, Rheumatoid Arthritis
Therapuetic Areas:Rheumatology
Healthy:No
Age Range:18 - Any
Updated:10/14/2017
Start Date:June 2005
End Date:September 2006

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Trial Summary
Trial Overview
Inclusion Criteria

A Phase III, 12-Week, Multicentre, Double-Blind, Randomised, Placebo- and Active Comparator-Controlled, Parallel Group Study to Investigate the Efficacy and Safety of GW406381, 5mg, 10mg, 25mg, and 50mg Administered Orally Once Daily, in Adults With Rheumatoid Arthritis

This study is being conducted to find out if an investigational drug called GW406381 can help
people with rheumatoid arthritis.


Inclusion criteria:

- Rheumatoid arthritis (RA) for at least 12 months.

- Required a non-steroidal anti-inflammatory drug (NSAID) or COX-2 inhibitor for RA for
at least 5 out of 7 days of each week for the 4 weeks prior to screening.

Exclusion criteria:

- Any history of cardiovascular disease (e.g., heart attack, stroke, congestive heart
failure, uncontrolled high blood pressure), documented peripheral arterial
insufficiency and symptomatic, clinically significant claudication, or who have a
history of peripheral arterial embolism.

- Have an active stomach ulcer or history of any stomach tear or bleeding.
We found this trial at
89
sites
GSK Investigational Site
Stuart, Florida 34994
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Anaheim, California 92807
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Anniston, Alabama 36207
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Atlanta, Georgia 30341
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Austin, Texas 78705
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Aventura, Florida 33180
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Berlin, New Jersey 08009
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Birmingham, Alabama 35249
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Bridgeport, Connecticut 06606
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Charleston, South Carolina 29425
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Charlotte, North Carolina 28203
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Cleveland, Ohio 44195
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Colorado Springs, Colorado 80910
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Columbus, Ohio 43219
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Concinnati, Ohio 45219
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Cordoba, Córdova
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Dallas, Texas 75230
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Danbury, Connecticut 06810
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Daytona Beach, Florida 32117
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DeLand, Florida 32720
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Dover, New Hampshire 03820
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Duncansville, Pennsylvania 16635
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Dunedin, Florida 34698
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Evanston, Illinois 60201
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Evansville, Indiana 47714
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Everett, Washington 98201
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Fall River, Massachusetts 02720
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Gainsville, Georgia 30501
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Gastonia, North Carolina 28054
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Glendale, Arizona 85304
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Greer, South Carolina 29651
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Hamden, Connecticut 06518
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Hampton, South Carolina 29924
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Hickory, North Carolina 28601
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Huntsville, Alabama 35801
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Idaho Falls, Idaho 83404
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Indianapolis, Indiana 46202
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Johnson City, New York 13790
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Kalamazoo, Michigan 49007
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Kingston, New York 12401
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Lansing, Michigan 48917
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Largo, Florida 33770
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Las Vegas, Nevada 89102
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Louisville, Kentucky 40202
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Mayfield Village, Ohio 44143
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Medford, Oregon 97504
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Memphis, Tennessee 38120
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Mercerville, New Jersey 08619
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Miami, Florida 33136
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Montgomery, Alabama 36109
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Morton Grove, Illinois 60053
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Murrells Inlet, South Carolina 29576
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New Orleans, Louisiana 70112
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New York, New York 10032
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North Massapequa, New York 11758
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Ocala, Florida 34471
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Oklahoma City, Oklahoma 73112
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Orlando, Florida 32806
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Palm Desert, California 92260
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Palm Harbor, Florida 34684
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Philadelphia, Pennsylvania 19104
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Port Orange, Florida 32129
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Prairie Village, Kansas 66208
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Racine, Wisconsin 53404
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Reno, Nevada 89502
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Rochester, New York 14642
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Roswell, Georgia 30076
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San Antonio, Texas 78258
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San Diego, California 92111
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Santa Monica, California 90404
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Scottsdale, Arizona 85259
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Slidell, Louisiana 70458
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Springfield, Illinois 62702
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Springfield, Massachusetts 01199
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St. Louis, Missouri 63110
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Statesville, North Carolina 28625
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Tampa, Florida 33612
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Trinity, Florida 34655
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Trumbull, Connecticut 06611
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Tucson, Arizona 85724
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Tulsa, Oklahoma 74105
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Upland, California 91786
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Vancouver, Washington 98684
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West Palm Beach, Florida 33409
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West Reading, Pennsylvania 19611
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Wheaton, Maryland 20902
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Wichita, Kansas 67207
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Woodstock, Georgia 30189
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Zephyrhills, Florida 33540
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