Effect of Supplemental Oxygen on Maximal Oxygen Consumption in Patients With Chronic Obstructive Pulmonary Disease
| Status: | Completed |
|---|---|
| Conditions: | Chronic Obstructive Pulmonary Disease, Pulmonary |
| Therapuetic Areas: | Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/17/2017 |
| Start Date: | August 2009 |
| End Date: | July 2010 |
Effect of Therapeutic Hyperoxia on Maximal Oxygen Consumption and Perioperative Risk Stratification in Patients With Chronic Obstructive Pulmonary Disease
Maximal consumption of oxygen (VO2max) during exercise is used in patients with chronic
obstructive pulmonary disease (COPD) to stratify perioperative risk. However, the impact of
supplemental oxygen to prevent hypoxemia during exercise on maximal oxygen consumption and
other ventilatory parameters during maximal exercise in the resting normoxic Chronic
Obstructive Pulmonary Disease population is poorly defined. The investigators performed a
randomized controlled trial in patients with COPD who underwent cardiopulmonary exercise
tests on room air and supplemental oxygen. The investigators compared maximal oxygen
consumption and other ventilatory parameters in each individual subject under the two
conditions.
obstructive pulmonary disease (COPD) to stratify perioperative risk. However, the impact of
supplemental oxygen to prevent hypoxemia during exercise on maximal oxygen consumption and
other ventilatory parameters during maximal exercise in the resting normoxic Chronic
Obstructive Pulmonary Disease population is poorly defined. The investigators performed a
randomized controlled trial in patients with COPD who underwent cardiopulmonary exercise
tests on room air and supplemental oxygen. The investigators compared maximal oxygen
consumption and other ventilatory parameters in each individual subject under the two
conditions.
Inclusion Criteria:
- Clinical diagnosis of Chronic Obstructive Pulmonary Disease (COPD).
- Pulmonary function characterized by forced expiratory volume in 1 second/forced vital
capacity ratio<0.7, and forced expiratory volume in one second <80% predicted.
Exclusion Criteria:
- Subjects with a recent COPD exacerbation requiring emergency department visit or
hospitalization within the last month.
- Subjects scheduled for a major pulmonary intervention in the next 3 months
- Subjects with severe peripheral vascular disease or other physical conditions that
would preclude exercise testing
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