Study to Evaluate Safety and Efficacy of Blinatumomab in Subjects With Relapsed/Refractory (R/R) Aggressive B-Cell NHL

This is a phase 2/3 open label, multicenter trial testing blinatumomab monotherapy for the
treatment of subjects with R/R aggressive B-NHL not achieving CMR after standard
platinum-based chemotherapy regimens administered as S1. This study incorporates multiple
interim analyses for futility, efficacy, and unblinded sample-size re-estimation. In the
phase 3 part of the study, blinatumomab will be compared to IC chemotherapy.The phase 2
component of the study will consist of up to a 28-day screening period, approximately 70 to
112 days of study treatment, a 30-day (+/- 3days) safety follow up, and long-term follow up
that will conclude with the final analysis of the phase 3 component, estimated at 30 months
after initiation of the phase 3 component. For the phase 3 component, the study will consist
of up to a 28-day screening period, a treatment period of up to approximately 168 days, a
30-day safety follow-up visit, and long-term follow up. Long-term follow up will conclude
with the final analysis.In the phase 2 component, enrolled subjects will receive blinatumomab
monotherapy. In the phase 3 component, enrolled subjects will be randomized in a 1:1 ratio to
blinatumomab or IC chemotherapy.

Inclusion Criteria:

- Biopsy proven aggressive B-cell Non-Hodgkin Lymphoma (B-NHL), including diffuse large
B-cell lymphoma (DLBCL) not otherwise specified (NOS), follicular lymphoma Grade 3B,
PMBCL, T-cell rich B-cell lymphoma, or DLBCL that represents transformation of
indolent non-Hodgkin's Lymphoma (NHL), (including follicular, marginal zone, and
lymphoplasmacytoid lymphoma) excluding chronic lymphocytic leukemia or Hodgkin
Lymphoma. The following histologies are not eligible:

- Lymphoblastic lymphoma

- Burkitt lymphoma

- Mantle cell lymphoma Any histologies not specifically mentioned must be discussed
with medical monitor.For subjects enrolled in the phase 3 portion of study,
pathologic samples will be submitted for central confirmation of disease
histology.

- Refractory (no prior CR/CMR) or relapsed (prior CMR) following front line treatment of
standard multiagent chemotherapy containing an anthracycline AND an approved anti-CD20
agent. For subjects with refractory disease and who have received radiotherapy, PET
positivity should be demonstrated no less than 6 weeks after the last dose of
radiotherapy

- Biopsy proven confirmation of relapsed disease.

- Received a minimum of 2 cycles of standard of care platinum-based chemotherapy in the
S1 setting and had a response of progressive metabolic disease (PMD), no metabolic
response (NMR), partial metabolic response (PMR) as centrally assessed by PET-/ CT
scan or received at least 1 cycle of S1 chemotherapy and had evidence of PMD as
centrally assessed. A pre-salvage scan is required to be submitted to the central
reader if a subject had only 1 cycle of pre-salvage chemotherapy.

- Radiographically measurable disease with a demarcated nodal lesion at least 1.5 cm in
its largest dimension or a target extranodal lesion at least 1.0 cm in its largest
dimension

- Eastern Cooperative Oncology Group performance status less than or equal to 2

- Intention to proceed to high dose chemotherapy (HDT) and autologous hematopoietic stem
cell transplant (HSCT)

- Laboratory parameters:

Hematology:

- Absolute neutrophil count (ANC) ≥ 1.0 x 10^9/L

- Platelets ≥ 75 x 10^9/L

Chemistry:

- Creatinine clearance ≥ 50 mL/min

- Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3X upper limit of
normal (ULN)

- Total bilirubin (TBL) < 2x ULN (unless Gilbert's disease or if liver involvement with
lymphoma)

Exclusion Criteria:

- CMR following S1 chemotherapy

- Treatment within 30 days prior to randomization with another investigational device or
drug study (ies).

- Prior anti-CD19-directed therapies

- Prior HDT with autologous HSCT

- Prior allogeneic HSCT

- Clinically relevant central nervous system (CNS) pathology such as epilepsy, paresis,
aphasia, stroke, severe brain injury, dementia, Parkinson's disease, cerebellar
disease, organic brain syndrome, or psychosis

- Evidence of CNS involvement by NHL

- Known infection with human immunodeficiency virus or chronic infection with hepatitis
B virus (hepatitis B surface antigen positive) or hepatitis C virus (anti hepatitis C
virus positive)

- History of malignancy other than B-NHL within the past 3 years with the exception of:

- Malignancy treated with curative intent and with no known active disease present
for ≥ 3 years before enrollment

- Adequately treated non-melanoma skin cancer or lentigo maligna

- Adequately treated cervical carcinoma in situ

- Adequately treated breast ductal carcinoma in situ

- Prostatic intraepithelial neoplasia without evidence of prostate cancer

- Adequately treated urothelial papillary non-invasive carcinoma or carcinoma in
situ

- Known sensitivity to immunoglobulins or any of the components to be administered
during dosing.

- Subject likely to not be available to complete all protocol-required study visits or
procedures, and/or to comply with all required procedures.

- History or evidence of any other clinically significant disorder, condition or disease
(with the exception of those outlined above) that would pose a risk to subject safety
or interfere with the study evaluation, procedures or completion.

- Female subjects who are pregnant or breastfeeding or planning to become pregnant or
breastfeed, or of childbearing potential unwilling to use an effective method of
contraception while receiving, and for an additional 48 hours after the last dose of
blinatumomab.