Lorcaserin in the Treatment of Cocaine Use Disorder

This is a 19-week, multi-center, randomized, Phase 2 clinical study comparing the efficacy of
lorcaserin (10mg, b.i.d) to matched placebo in the treatment of cocaine use disorder. Up to 3
weeks will be allowed for the Screening Period and a 13-week treatment phase, with a 3-week
follow-up period, with scheduled visits during Study weeks 14 and 16.

Inclusion Criteria:

- Has a DSM-5 diagnosis of current cocaine use disorder as verified by the Structured
Clinical Interview for DSM-5

- Is seeking treatment for cocaine use disorder

- Is able to understand and provide written informed consent

- Has used cocaine on at least 1 day in the last 30 days prior to screening

- Has completed all psychological assessments and procedures during the screening period

- If female, not pregnant, lactating, unable to conceive OR must agree to use an
acceptable method of birth control

- Has a total body weight greater than 110 pounds and body mass index greater than 20

Exclusion Criteria:

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