Taste And Smell TEsting in End Stage Renal Disease
| Status: | Recruiting |
|---|---|
| Conditions: | Food Studies, Other Indications, Renal Impairment / Chronic Kidney Disease, Renal Impairment / Chronic Kidney Disease, Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology, Pharmacology / Toxicology, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/18/2017 |
| Start Date: | February 15, 2017 |
| End Date: | February 6, 2021 |
| Contact: | Katherine Lynch, MD, SM |
| Email: | kelynch@bidmc.harvard.edu |
| Phone: | 617-632-9845 |
TASTE ESRD: Taste And Smell TEsting in End Stage Renal Disease
Malnutrition is an important complication of advanced kidney disease and impairment in smell
and taste may affect nutritional status. This study will examine the association between
impairment in smell and taste and nutritional and functional markers among patients with end
stage renal disease, as well as risk factors for smell and taste impairment.
and taste may affect nutritional status. This study will examine the association between
impairment in smell and taste and nutritional and functional markers among patients with end
stage renal disease, as well as risk factors for smell and taste impairment.
People with advanced chronic kidney disease (CKD) are at risk for malnutrition, which is
associated with significantly increased mortality. Impairments in olfaction and taste are
under-recognized and under-addressed symptoms that affect this population. Olfaction and
taste influence appetite and nutritional status and represent a unique target for study and
intervention. Small cross-sectional studies have shown a higher prevalence of olfactory (up
to 56%) and taste disturbances (up to 35%) among patients with CKD compared with the general
population, but little is known about longitudinal change in olfaction and taste in this
population. Additionally, there is a lack of understanding about why these sensory
disturbances more commonly occur in people with CKD, although there is speculation that
uremia may contribute.
This information gained from this study will address these gaps in knowledge by studying
longitudinal changes in olfaction and taste and their associations with concurrent and
future nutritional and functional status. Additionally this study will attempt to identify
potentially modifiable risk factors associated with olfactory and taste impairment.
associated with significantly increased mortality. Impairments in olfaction and taste are
under-recognized and under-addressed symptoms that affect this population. Olfaction and
taste influence appetite and nutritional status and represent a unique target for study and
intervention. Small cross-sectional studies have shown a higher prevalence of olfactory (up
to 56%) and taste disturbances (up to 35%) among patients with CKD compared with the general
population, but little is known about longitudinal change in olfaction and taste in this
population. Additionally, there is a lack of understanding about why these sensory
disturbances more commonly occur in people with CKD, although there is speculation that
uremia may contribute.
This information gained from this study will address these gaps in knowledge by studying
longitudinal changes in olfaction and taste and their associations with concurrent and
future nutritional and functional status. Additionally this study will attempt to identify
potentially modifiable risk factors associated with olfactory and taste impairment.
Inclusion Criteria:
- Aged 18 or older
- End-stage renal disease requiring chronic dialysis
Exclusion Criteria:
- Known allergy to quinine
- Presence of a pacemaker or internal defibrillator
- Pregnancy or breastfeeding
We found this trial at
1
site
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
Click here to add this to my saved trials
