High Quality Protein for Assisting With Weight Loss
| Status: | Recruiting |
|---|---|
| Conditions: | Obesity Weight Loss |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 18 - 44 |
| Updated: | 4/17/2018 |
| Start Date: | August 20, 2017 |
| End Date: | May 2019 |
| Contact: | Nikhil Dhurandhar, PhD |
| Email: | nikhil.dhurandhar@ttu.edu |
| Phone: | 8068346446 |
Does Higher Protein Quality Reduce Energy Intake When Following a Weight Loss Diet Plan? -- Nonpilot, Powered Crossover
The purpose of this study is to determine if, in presence of a reduced calorie diet, a
breakfast containing high quality protein source (eggs) would be more effective in reducing
hunger and increasing feeling of fullness compared to a breakfast containing a lower quality
of protein, but equal energy density. A previous pilot study with the same endpoints yielded
borderline significant results; this study has been powered based on that pilot to
interrogate our hypotheses.
breakfast containing high quality protein source (eggs) would be more effective in reducing
hunger and increasing feeling of fullness compared to a breakfast containing a lower quality
of protein, but equal energy density. A previous pilot study with the same endpoints yielded
borderline significant results; this study has been powered based on that pilot to
interrogate our hypotheses.
This will be a crossover study with 2 experiments. Subjects will follow a reduced energy
weight loss diet of 1,200-1,500 kcal adjusted to each individual's body weight for totally 2
weeks in each experiment. They will come to the clinic from day 1 to day 7 and consume egg
breakfast (EB) for 5 days under our supervision. Then on weekends during this period they
will continue this breakfast at home based on our advice. The next week they will have cereal
breakfast (CB) and the process is similar to that in the first week.
The 1st experiment will test the satiety from egg breakfast (EB) and following energy intake
in both lunch and dinner, compared with CB (cereal breakfast). Lunch and dinner will be
offered on 2 test days during each week. Anthropometric and body composition measurements,
blood pressure, blood draw, satiety questionnaire, as well as energy intake will also be
collected in the 2 test days and compared between 2 breakfast groups.
The 2nd one is to test whether EB will help in resisting the intake of foods considered
tempting, but detrimental to weight loss efforts, compared with CB. The process is similar to
experiment 1 except no blood draw, no dinner offered. Instead, a tempting food after lunch
will be offered.
weight loss diet of 1,200-1,500 kcal adjusted to each individual's body weight for totally 2
weeks in each experiment. They will come to the clinic from day 1 to day 7 and consume egg
breakfast (EB) for 5 days under our supervision. Then on weekends during this period they
will continue this breakfast at home based on our advice. The next week they will have cereal
breakfast (CB) and the process is similar to that in the first week.
The 1st experiment will test the satiety from egg breakfast (EB) and following energy intake
in both lunch and dinner, compared with CB (cereal breakfast). Lunch and dinner will be
offered on 2 test days during each week. Anthropometric and body composition measurements,
blood pressure, blood draw, satiety questionnaire, as well as energy intake will also be
collected in the 2 test days and compared between 2 breakfast groups.
The 2nd one is to test whether EB will help in resisting the intake of foods considered
tempting, but detrimental to weight loss efforts, compared with CB. The process is similar to
experiment 1 except no blood draw, no dinner offered. Instead, a tempting food after lunch
will be offered.
Inclusion Criteria:
- Overweight and class I-II obese (BMI 25.0-39.9)
- Sedentary (<3 hours/week of moderate intensity physical activity)
- Otherwise healthy
Exclusion Criteria:
- ≥5% body weight loss or gain in the three months preceding the study
- Post-menopausal (has not had period for 12 months)
- Plans to begin an exercise program or change current exercise routines between
initiation of study and final study
- Anyone following a medical diet prescription
- Anyone with a chronic disease including type II diabetes, hypothyroidism,
hypoparathyroidism, cardiovascular disease, cancer of any type
- Health conditions and chronic illness that contraindicate behavioral weight loss
treatment using a low calorie diet: Unstable cardiac condition; Polycystic ovary
syndrome; Prader-Willi syndrome; Major systemic illness; History of recreational drug
abuse or eating disorder (Binge Eating Disorder); Familial hyperlipidemia; Major
endocrine diseases (Cushing's syndrome, Grave's disease, Hashimoto's thyroiditis);
Gastrointestinal disorder
- Anyone who is currently pregnant, or lactating
- Medications that may influence or inhibit appetite, sensory functioning, or hormone
signaling
- Plans to begin taking any supplements that may influence weight loss
- Report of medical condition or surgical intervention that affects swallowing or
chewing ability
- Anyone with a pacemaker or other internal medical device
- Any practicing vegans or vegetarians
- Any practicing gluten-free diet
- Allergy, aversion, or dislike to any of the foods offered for meals
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