Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure
| Status: | Terminated |
|---|---|
| Conditions: | High Blood Pressure (Hypertension), Hospital, Hospital, Neurology, Neurology, Pulmonary |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology, Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/24/2019 |
| Start Date: | February 2016 |
| End Date: | August 2, 2018 |
The purpose of this study is to collect physiologic data from patients with severe brain
injury who require mechanical ventilation in order to describe the impact of ventilation,
specifically positive end expiratory pressure (PEEP), on intracranial pressure (ICP).
injury who require mechanical ventilation in order to describe the impact of ventilation,
specifically positive end expiratory pressure (PEEP), on intracranial pressure (ICP).
Inclusion Criteria:
- Patients with severe brain injury (GCS 8 or less)
- Receiving mechanical ventilation
- Receiving intracranial pressure monitoring
Exclusion Criteria:
- Esophageal varices
- Esophageal trauma
- Recent esophageal surgery
- Coagulopathy (Platelets < 80k or INR> 2 )
- Other contraindication for esophageal manometry
- Already receiving PEEP > 15 cmH2O at enrollment
- Intracranial hypertension (defined as ICP > 20 mmHg)
- Decompressive hemi-craniectomy
We found this trial at
1
site
330 Brookline Ave
Boston, Massachusetts 02215
Boston, Massachusetts 02215
617-667-7000
Phone: 617-754-2751
Beth Israel Deaconess Medical Center Beth Israel Deaconess Medical Center (BIDMC) is one of the...
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