Effect of Vitamin D After Application With Valchlor
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 11/22/2017 |
| Start Date: | November 17, 2016 |
| End Date: | December 15, 2018 |
| Contact: | Kurt Lu, MD |
| Email: | kurt.lu@uhhospitals.org |
| Phone: | 216-368-2333 |
The Effect of Oral Vitamin D (Cholecalciferol) Supplementation After Topical Application With Valchlor
The purpose of this research study is to evaluate the effects of an oral Vitamin D on the
body's immune system.
An interest has been growing because studies have shown that Vitamin D may reduce
inflammation and harmful effects in the body, however, the best dose for Vitamin D is still
unknown.
Inflammation is the body's physical response to infection, injury, or long term disease.
Pain, redness, heat, and sometimes loss of function are all signs of inflammation in the
body. This study will look at product use, testing skin irritation in healthy volunteers and
seeing how Vitamin D may help stop or reduce inflammation and skin irritation, which could
one day help doctors prescribe Vitamin D to patients with long term disease to relieve their
symptoms.
body's immune system.
An interest has been growing because studies have shown that Vitamin D may reduce
inflammation and harmful effects in the body, however, the best dose for Vitamin D is still
unknown.
Inflammation is the body's physical response to infection, injury, or long term disease.
Pain, redness, heat, and sometimes loss of function are all signs of inflammation in the
body. This study will look at product use, testing skin irritation in healthy volunteers and
seeing how Vitamin D may help stop or reduce inflammation and skin irritation, which could
one day help doctors prescribe Vitamin D to patients with long term disease to relieve their
symptoms.
Primary Endpoint To determine the effect of a topical application of Valchlor on human
subjects at the clinically approved dose.
Secondary Endpoint To establish the efficacy of cholecalciferol (vitamin D3) in reducing skin
irritation 48 hours after topical application of Valchlor.
subjects at the clinically approved dose.
Secondary Endpoint To establish the efficacy of cholecalciferol (vitamin D3) in reducing skin
irritation 48 hours after topical application of Valchlor.
Inclusion Criteria:
- Must be in general good health
- Fitzpatrick Skin Type I-VI
- Able to list all current medications and medical conditions
- Capable of giving informed consent
Exclusion Criteria:
- Women who are pregnant, nursing, or who may become pregnant in the next 3 months
- Participants taking illegal drugs
- Currently taking ketoconazole, colestipol, cholestyramine, phenobarbitol, phenytoin,
or mineral oil
- Currently consuming 800IU or more of vitamin D a day
- Subjects whose BMI are > 40
We found this trial at
1
site
Cleveland, Ohio 44106
Principal Investigator: Kurt Lu, MD
Phone: 216-368-2333
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