Exercise Testing for Early Stage Breast Cancer Patients Receiving Radiation Treatment

Inclusion Criteria:

- Female

- ECOG performance status 0 or 1

- Medical clearance from attending radiation oncologist or medical oncologist to undergo
a symptom-limited CPET

- Currently undergoing intact breast radiotherapy for early stage breast cancer
(including TisN0, T1N0, T2N0) or has completed intact breast RT in the last 3 months.

- Receiving or received a prescribed dose of 4240 cGy in 16 fractions to the whole
breast without treatment directed at nodal basins. Patients may also be receiving or
have received a boost to the lumpectomy bed at the discretion of the treating
physician.

- Subjects may be treated in the supine or prone position at the discretion of the
treating physician.

- Subjects may be treated with or without a deep inspiratory breath hold technique at
the discretion of the treating physician.

- Identified by the treating radiation oncologist as having significant
treatment-related fatigue or minimal treatment-related fatigue and not simply baseline
fatigue. A score of "0" on the RTOG fatigue scale will be considered minimal fatigue,
while a score of "2" or greater will be considered significant fatigue (moderate
fatigue causing difficulty performing some ADLs).

Exclusion Criteria:

- Currently undergoing post-mastectomy radiation

- Has received chemotherapy previously or has a plan to receive chemotherapy during the
timeframe of study assessment.

- Any of the following absolute contraindications to CPET, as per American Thoracic
Society (ATS) recommendations

- Acute myocardial infarction (within 3-5 days of any planned study procedures)

- Unstable angina

- Uncontrolled arrhythmia causing symptoms or hemodynamic compromise

- Recurrent syncope

- Active endocarditis

- Acute myocarditis or pericarditis

- Symptomatic severe aortic stenosis

- Uncontrolled heart failure

- Acute pulmonary embolus or pulmonary infarction within 3 months of any planned
study procedures

- Thrombosis of lower extremities

- Suspected dissecting aneurysm

- Uncontrolled asthma

- Pulmonary edema

- Room air desaturation at rest ≤ 85%

- Respiratory failure

- Acute non-cardiopulmonary disorders that may affect exercise performance or be
aggravated by exercise (i.e. infection, renal failure, thyrotoxicosis)

- Mental impairment leading to inability to cooperate