The Effect of Blood Flow Restriction Training on Muscle Atrophy Following Knee Surgery
| Status: | Recruiting |
|---|---|
| Conditions: | Neurology, Orthopedic |
| Therapuetic Areas: | Neurology, Orthopedics / Podiatry |
| Healthy: | No |
| Age Range: | 18 - 50 |
| Updated: | 2/10/2019 |
| Start Date: | April 5, 2017 |
| End Date: | August 12, 2020 |
| Contact: | John S Mason, DSc, DPT |
| Email: | john.s.mason14.mil@mail.mil |
| Phone: | 845-938-3067 |
The Effect of Blood Flow Restriction Training on Muscle Atrophy Following Knee Surgery; A Randomized Control Trial
The investigators will compare differences in quadriceps strength, leg girth, and functional
outcome scores between two groups of patients after weeks 6 and 12 as well as 6 months
following meniscus or articular cartilage repair/restoration requiring 6 weeks of non-weight
bearing or limited weight bearing status in a brace at 0° degrees of knee extension. One
group will receive BFR with standard post-operative rehabilitation for 12 weeks followed by
the standard protocol progression for the remainder of the treatment program. The other group
will receive standard post-operative rehabilitation without BFR for the duration of treatment
program.
outcome scores between two groups of patients after weeks 6 and 12 as well as 6 months
following meniscus or articular cartilage repair/restoration requiring 6 weeks of non-weight
bearing or limited weight bearing status in a brace at 0° degrees of knee extension. One
group will receive BFR with standard post-operative rehabilitation for 12 weeks followed by
the standard protocol progression for the remainder of the treatment program. The other group
will receive standard post-operative rehabilitation without BFR for the duration of treatment
program.
The aim is to compare strength, patient reported outcomes, and functional outcomes of
post-operative therapy with and without adjunctive BFR training. To accomplish this task the
investigators will compare differences in thigh girth between two groups of patients after
the first 6 weeks and 12 weeks as well as 6 months following meniscus or articular cartilage
repair requiring 6 weeks of non-weight bearing or limited weight bearing status in a brace at
0˚ degrees of extension. In addition, isokinetic testing of the quadriceps and hamstrings
will be performed at 12 weeks and 6 months post-operatively. Lower extremity girth
measurements after knee surgery can be performed with good to excellent intra- and
inter-rater reliability. Quadriceps strength measured with isokinetic testing is related to
performance measures such as jumping. Limb circumference measurement, limb CSA measurement,
and isokinetic strength testing are commonly utilized in BFR studies as outcome measures.One
group will receive BFR for 12 weeks in addition to standard post-operative rehabilitation and
the other group will receive standard post-operative rehabilitation without BFR.
post-operative therapy with and without adjunctive BFR training. To accomplish this task the
investigators will compare differences in thigh girth between two groups of patients after
the first 6 weeks and 12 weeks as well as 6 months following meniscus or articular cartilage
repair requiring 6 weeks of non-weight bearing or limited weight bearing status in a brace at
0˚ degrees of extension. In addition, isokinetic testing of the quadriceps and hamstrings
will be performed at 12 weeks and 6 months post-operatively. Lower extremity girth
measurements after knee surgery can be performed with good to excellent intra- and
inter-rater reliability. Quadriceps strength measured with isokinetic testing is related to
performance measures such as jumping. Limb circumference measurement, limb CSA measurement,
and isokinetic strength testing are commonly utilized in BFR studies as outcome measures.One
group will receive BFR for 12 weeks in addition to standard post-operative rehabilitation and
the other group will receive standard post-operative rehabilitation without BFR.
Inclusion Criteria:
- Military healthcare beneficiaries between the age of 18 and 50 years.
- Must intend to remain on station at location of surgery for 6 months from date of
surgery.
- Meniscus repair or cartilage restoration technique to include microfracture,
osteochondral autograft transfer system, osteochondral allograft transplantation, and
autologous chondrocyte implantation following standard post-operative protocol
guidelines requiring a 6 week period of non-weight bearing or limited weight bearing
in a brace at 0˚ degrees of extension.
Exclusion Criteria:
- Concomitant ligamentous repair/reconstruction
- Known pregnancy
- Any medical condition for which aerobic exercise is contraindicated
- Additional back, hip, or knee surgery in the previous 12 months
- History of vascular or cardiac impairment
We found this trial at
3
sites
Fort Bragg, North Carolina
Principal Investigator: John S Mason, DSc
Phone: 910-907-9475
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Fort Bliss, Texas 79920
Principal Investigator: Patrick Keenan, DPT
Phone: 915-742-2181
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West Point, New York 10996
Principal Investigator: John S Mason, DSc
Phone: 845-938-3067
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