Adaptive Radiotherapy for Head and Neck Cancer

Inclusion Criteria:

- Participants with pathologically confirmed cancers of paranasal sinuses, oropharynx,
oral cavity, nasopharynx, larynx, hypopharynx, and unknown primary and will receive
definitive radiation therapy with or without chemotherapy.

- Karnofsky performance status >= 70%

- Women of childbearing potential need to have a negative serum pregnancy test at the
time of therapy

- Participants must have the ability to understand and the willingness to sign a written
consent form

Exclusion Criteria:

- Female participants who are pregnant or breast feeding

- Participants who are not able to comply with study and/or follow up procedures

- Participants who have received induction chemotherapy before radiation treatment

- Participants who had prior head and neck radiation therapy

- Participants who are enrolled in a national/international cooperative group trials

- Patients with metastatic disease