Pembrolizumab and Carboplatin in Treating Patients With Relapsed or Refractory Ovarian, Fallopian Tube, or Primary Peritoneal Cancer

PRIMARY OBJECTIVES:

I. To determine the clinical response rate of platinum chemotherapy and pembrolizumab
(MK-3475) in platinum chemotherapy pretreated ovarian, fallopian tube, and primary
peritoneal.

II. To examine whether retreatment with platinum chemotherapy in platinum resistant ovarian,
fallopian tube, and primary peritoneal cancers improves progression free survival by
concurrent administration of MK-3475.

SECONDARY OBJECTIVES:

I. To assess the safety and tolerability of concurrent administration of MK-3475 with
platinum chemotherapy in patients with platinum resistant recurrent ovarian, fallopian tube,
and primary peritoneal cancers.

II. To determine the relationship between PD-L1 expression and response to the combination of
MK-3475 and platinum.

III. To assess the overall survival of patients treated with the combination of MK-3475 and
platinum.

EXPLORATORY OBJECTIVES:

I. To explore changes in gene expression of pre and post treatment tumor samples.

II. To explore whether treatment with MK-3475 and platinum alters soluble factors in sera,
peripheral immune responses and immune cell profile.

OUTLINE:

Patients receive pembrolizumab intravenously (IV) over 30 minutes on day 1 and carboplatin IV
over 30 minutes on days 8 and 15. Courses repeat every 21 days for up to 24 months in the
absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up at 30 days, every 3 months for
1 year, every 6 months for 1 year, and then every 12 weeks thereafter.

Inclusion Criteria:

- Have a diagnosis of ovarian, fallopian tube, or primary peritoneal cancer patients who
had a complete response to primary treatment with platinum based chemotherapy, have
progressed within 6 months of completing platinum based chemotherapy and have
subsequently received at least one, non-platinum-based, therapy

- Have relapsed, refractory, or progressive disease following last line of treatment

- Have estimated life expectancy of at least 3 months

- Be willing and able to provide written informed consent/assent for the trial

- Have measurable disease with at least 1 unidimensional lesion based on Response
Evaluation Criteria in Solid Tumors (RECIST) 1.1

- Have a performance status of 0 or 1 on the Eastern Cooperative Oncology Group (ECOG)
performance scale

- Within 10 days of treatment initiation: Absolute neutrophil count (ANC) >= 1,500/mcL

- Within 10 days of treatment initiation: Platelets >= 100,000/mcL

- Within 10 days of treatment initiation: Hemoglobin >= 9 g/dL or >= 5.6 mmol/L without
transfusion or erythropoietin (EPO) dependency (within 7 days of assessment)

- Within 10 days of treatment initiation: Serum creatinine =< 1.5 X upper limit of
normal (ULN) OR measured or calculated creatinine clearance (glomerular filtration
rate [GFR] can also be used in place of creatinine or creatinine clearance [CrCl]) >=
60 mL/min for subject with creatinine levels > 1.5 X institutional ULN

- Within 10 days of treatment initiation: Serum total bilirubin =< 1.5 X ULN OR direct
bilirubin =< ULN for subjects with total bilirubin levels > 1.5 ULN

- Within 10 days of treatment initiation: Aspartate aminotransferase (AST) (serum
glutamic-oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum
glutamate pyruvate transaminase [SGPT]) =< 2.5 X ULN OR =< 5 X ULN for subjects with
liver metastases

- Within 10 days of treatment initiation: Albumin >= 2.5 mg/dL

- Within 10 days of treatment initiation: International normalized ratio (INR) or
prothrombin time (PT) =< 1.5 X ULN unless subject is receiving anticoagulant therapy
as long as PT or partial thromboplastin time (PTT) is within therapeutic range of
intended use of anticoagulants

- Within 10 days of treatment initiation: Activated partial thromboplastin time (aPTT)
=< 1.5 X ULN unless subject is receiving anticoagulant therapy as long as PT or PTT is
within therapeutic range of intended use of anticoagulants

- Female subject of childbearing potential should have a negative urine or serum
pregnancy within 72 hours prior to receiving the first dose of study medication; if
the urine test is positive or cannot be confirmed as negative, a serum pregnancy test
will be required

- Female subjects of childbearing potential should be willing to use 2 methods of birth
control or be surgically sterile, or abstain from heterosexual activity for the course
of the study through 120 days after the last dose of study medication; subjects of
childbearing potential are those who have not been surgically sterilized or have not
been free from menses for > 1 year

Exclusion Criteria:

- Is currently participating and receiving study therapy or has participated in a study
of an investigational agent and received study therapy within 4 weeks of the first
dose of treatment

- Has a diagnosis of immunodeficiency or is receiving systemic steroid therapy or any
other form of immunosuppressive therapy within 7 days prior to the first dose of trial
treatment

- Short-term administration of systemic steroids (i.e., for allergic reactions or
the management of immune related adverse events [irAEs]) is allowed

- Has a known history of active TB (Bacillus tuberculosis)

- Hypersensitivity to pembrolizumab or any of its excipients

- Has had a prior anti-cancer monoclonal antibody (mAb) within 4 weeks prior to study
day 1 or who has not recovered (i.e., =< grade 1 or at baseline) from adverse events
due to agents administered more than 4 weeks earlier

- Has had prior chemotherapy, targeted small molecule therapy, or radiation therapy
within 2 weeks prior to study day 1 or who has not recovered (i.e., =< grade 1 or at
baseline) from adverse events due to a previously administered agent

- Note: subjects with =< grade 2 neuropathy are an exception to this criterion and
may qualify for the study

- Note: if subject received major surgery, they must have recovered adequately from
the toxicity and/or complications from the intervention prior to starting therapy

- Has a known additional malignancy that is progressing or requires active treatment;
exceptions include basal cell carcinoma of the skin or squamous cell carcinoma of the
skin that has undergone potentially curative therapy or in situ cervical cancer

- Has known active central nervous system (CNS) metastases and/or carcinomatous
meningitis; subjects with previously treated brain metastases may participate provided
they are stable (without evidence of progression by imaging for at least four weeks
prior to the first dose of trial treatment and any neurologic symptoms have returned
to baseline), have no evidence of new or enlarging brain metastases, and are not using
steroids for at least 7 days prior to trial treatment; this exception does not include
carcinomatous meningitis which is excluded regardless of clinical stability

- Has active autoimmune disease that has required systemic treatment in the past 2 years
(i.e. with use of disease modifying agents, corticosteroids or immunosuppressive
drugs); replacement therapy (e.g., thyroxine, insulin, or physiologic corticosteroid
replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a
form of systemic treatment

- Has a history of (non-infectious) pneumonitis that required steroids or current
pneumonitis

- Has an active infection requiring systemic therapy

- Has a history or current evidence of any condition, therapy, or laboratory abnormality
that might confound the results of the trial, interfere with the subject's
participation for the full duration of the trial, or is not in the best interest of
the subject to participate, in the opinion of the treating investigator

- Has known psychiatric or substance abuse disorders that would interfere with
cooperation with the requirements of the trial

- Is pregnant or breastfeeding, or expecting to conceive children within the projected
duration of the trial, starting with the pre-screening or screening visit through 120
days after the last dose of trial treatment

- Clinically significant cardiovascular disease

- Known severe hypersensitivity reactions to monoclonal antibodies or carboplatin >=
grade 3, any history of anaphylaxis, or uncontrolled asthma

- Has received prior therapy with pembrolizumab

- Has a known history of human immunodeficiency virus (HIV) (HIV 1/2 antibodies)

- Has known active hepatitis B (e.g., hepatitis B surface antigen [HBsAg] reactive) or
hepatitis C (e.g., hepatitis C virus [HCV] ribonucleic acid [RNA] [qualitative] is
detected)

- Has received a live vaccine within 30 days of planned start of study therapy

- Note: seasonal influenza vaccines for injection are generally inactivated flu
vaccines and are allowed; however intranasal influenza vaccines (e.g., Flu-Mist)
are live attenuated vaccines, and are not allowed