Efficacy of Er:YAG Laser in Decontamination of Dental Implants: An In-Vitro Study
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 1/13/2018 |
| Start Date: | April 20, 2017 |
| End Date: | December 2018 |
| Contact: | Amanda Gozzi |
| Email: | Amanda.Gozzi@tufts.edu |
| Phone: | 6176362147 |
The American Association of Oral and Maxillofacial Surgeons estimated that 69% of adults ages
35 to 44 have lost at least one permanent tooth. Dental implants have revolutionized
dentistry by providing tooth-like replacement for missing teeth and a solution that is
predictable with long-term success..
After the implant is placed, natural bacteria from the mouth can develop around implants just
like around natural teeth. Studies have shown that bacterial contamination can cause
peri-implantitis- gum disease or inflammation around the implant, eventually leading to bone
loss. Removing bacteria from dental implant surfaces can prevent peri-implantitis, and
surface debridement constitutes the basis of treatment of peri-implant disease.
Typically, mechanical hand instrumentation using curettes to remove biofilm and calculus is
the main basis for periodontal therapy. However, total debridement is difficult, and the hand
tools may damage the surface of the implant and making it more plaque retentive. Studies have
shown that mechanical non-surgical therapy alone is not sufficient to treat peri-implantitis.
There is evidence that a dental laser may be an effective method to remove bacteria from
implant surfaces, with less damage to the surface. One type of dental laser, Er:YAG, appears
optimal for implant decontamination as the Er:YAG laser energy is primarily absorbed by
water, resulting in vaporization of bacteria and minimal surface alterations on the implant
surface.The aim of this study is to evaluate the efficiency of biofilm decontamination of
Er:YAG laser compared to carbon fiber curette.
35 to 44 have lost at least one permanent tooth. Dental implants have revolutionized
dentistry by providing tooth-like replacement for missing teeth and a solution that is
predictable with long-term success..
After the implant is placed, natural bacteria from the mouth can develop around implants just
like around natural teeth. Studies have shown that bacterial contamination can cause
peri-implantitis- gum disease or inflammation around the implant, eventually leading to bone
loss. Removing bacteria from dental implant surfaces can prevent peri-implantitis, and
surface debridement constitutes the basis of treatment of peri-implant disease.
Typically, mechanical hand instrumentation using curettes to remove biofilm and calculus is
the main basis for periodontal therapy. However, total debridement is difficult, and the hand
tools may damage the surface of the implant and making it more plaque retentive. Studies have
shown that mechanical non-surgical therapy alone is not sufficient to treat peri-implantitis.
There is evidence that a dental laser may be an effective method to remove bacteria from
implant surfaces, with less damage to the surface. One type of dental laser, Er:YAG, appears
optimal for implant decontamination as the Er:YAG laser energy is primarily absorbed by
water, resulting in vaporization of bacteria and minimal surface alterations on the implant
surface.The aim of this study is to evaluate the efficiency of biofilm decontamination of
Er:YAG laser compared to carbon fiber curette.
The aim of this study is to compare the amount of residual biofilm on titanium discs after
decontamination with Er:YAG laser and carbon fiber curette.
In the first phase of the study, custom mouth guards that holds multiple titanium discs will
be fabricated. Experimental subjects will be instructed to wear this mouth guard for 72
hours, during which time a natural bacterial biofilm will form on the disc surfaces.
The second phase of the study will be performed ex vivo after collecting the discs from the
subjects. Discs retrieved from each mouth guard will be randomized over the 4 treatment
groups, so that each subject will contribute two discs to each treatment group: 1) Er:YAG
laser, 2) carbon fiber curette, 3) combination of carbon fiber curette and Er:YAG laser, and
4) no treatment (control). The biofilm will be stained and the residual biofilm will be
visualized under fluorescence microscopy. Statistical methods will be used to determine the
significance of each treatment modality.
The primary outcome of the study is the percent area of the titanium disc covered by biofilm.
decontamination with Er:YAG laser and carbon fiber curette.
In the first phase of the study, custom mouth guards that holds multiple titanium discs will
be fabricated. Experimental subjects will be instructed to wear this mouth guard for 72
hours, during which time a natural bacterial biofilm will form on the disc surfaces.
The second phase of the study will be performed ex vivo after collecting the discs from the
subjects. Discs retrieved from each mouth guard will be randomized over the 4 treatment
groups, so that each subject will contribute two discs to each treatment group: 1) Er:YAG
laser, 2) carbon fiber curette, 3) combination of carbon fiber curette and Er:YAG laser, and
4) no treatment (control). The biofilm will be stained and the residual biofilm will be
visualized under fluorescence microscopy. Statistical methods will be used to determine the
significance of each treatment modality.
The primary outcome of the study is the percent area of the titanium disc covered by biofilm.
Inclusion Criteria:
- Presence of enough teeth to support the mouth guard.
- Subjects diagnosed with clinical health, gingivitis, or slight chronic periodontitis
defined as periodontal inflammation with slight (1-2mm) attachment loss.
Exclusion Criteria:
- Subjects with insufficient dental support for the mouth guard
- Subjects diagnosed with moderate or severe chronic periodontitis.
- Subjects with known allergy to acrylic or titanium.
- Subjects who smoke cigarettes, cigars, snuff tobacco, or any other form of smoking.
- Subjects with a history of antibiotic treatment within the last six months.
- Subjects with contraindications to wearing a mouth guard, such as chronic obstructive
pulmonary disease or severe sleep apnea.
- Subjects with uncontrolled or debilitating medical conditions, including but not
limited to subjects with uncontrolled diabetes, hematologic disorders, cancers,
immunosuppression, severe cardiovascular disease, or uncontrolled thyroid disease
- Subjects that are currently pregnant according to self-report
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