A Dose Escalation, Dose Expansion Study to Evaluate the Safety, Tolerability, and Antitumor Activity of MEDI-575, in Subjects With Advanced Tumors.

Inclusion Criteria:

- Histologically confirmed advanced solid tumor for which no curative or standard
therapies exist

- Karnofsky performance status of ≥ 60

- Life expectancy of >12 weeks

- Adequate hematologic and organ function

- Negative serum pregnancy test (women only)

- Two methods of birth control for female participants of child-bearing potential or
male participants with their female partners of child-bearing potential

Exclusion Criteria:

- Prior chemotherapy or investigational treatment within 4 weeks of study drug
administration

- Prior biological or immunological treatment within 6 weeks of study drug
administration

- Concurrent therapy for of cancer

- Major surgery within four weeks or minor surgery within two weeks of study drug
administration

- History of diabetes or current treatment for diabetes

- New York Heart Association ≥ Grade 2 congestive heart failure

- History of myocardial infarction, unstable angina, transient ischemic attack or stroke
within the previous 6 months prior to study entry

- History of other invasive malignancy within 5 years (exceptions are cervical carcinoma
in situ, non-melanomatous carcinoma of the skin or ductal carcinoma in situ of the
breast that are surgically cured)

- Significant active infection

- Known brain metastases

- Pregnancy or lactation or plans to become pregnant while on study

- Clinically significant abnormality on ECG