PRediction of Opioid-induced Respiratory Depression In Patients Monitored by capnoGraphY

Inclusion Criteria:

1. Patients receiving parenteral opioid therapy (for post-surgical or non-surgical) pain
on the hospital ward.

2. Adult age (≥18 year old in US and Europe; ≥20 years old in Japan; ≥21 years old in
Singapore).

3. Patient is able and willing to give informed consent.

Exclusion Criteria:

1. Expected length of stay ≤ 24 hours.

2. Patient is receiving intrathecal opioids.

3. Post-surgical patients with American Society of Anesthesiologists physical status (ASA
PS) V or higher.

4. Patients with the status of Do Not Resuscitate (DNR), hospice, or receiving end of
life therapy.

5. Ventilated or intubated patients.

6. Patient is unwilling or unable to comply fully with study procedures (including
non-toleration of the capnography cannula) due to any disease condition which can
raise doubt about compliance and influencing the study outcome.

7. Patient is a member of a vulnerable population, including legal incapacity or evidence
that a subject cannot understand the purpose and risks of the study, regardless of
authorized representative support.

8. Patient is participating in another potentially confounding drug or device clinical
study.