First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOX



Status:Completed
Conditions:Colorectal Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 127
Updated:4/15/2017
Start Date:August 30, 2006
End Date:August 19, 2015

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A Randomised, Double-blind, Multicentre Phase II/III Study to Compare the Efficacy of Cediranib (RECENTIN™, AZD2171) in Combination With 5-fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX), to the Efficacy of Bevacizumab in Combination With FOLFOX in Patients With Previously Untreated Metastatic Colorectal Cancer

The purpose of this study is to see if Cediranib in combination with FOLFOX is effective in
treating metastatic colorectal cancer and to see how it compares with Avastin (Bevacizumab)
in combination with FOLFOX.


Inclusion Criteria:

- Clinical Diagnosis of colon or rectal cancer

- No prior systemic therapy for metastatic disease. Any adjuvant/neoadjuvant
oxaliplatin therapy must have been received >12 months prior to study entry and
adjuvant/neoadjuvant 5-FU must have been received >6 months prior to study entry.

Exclusion Criteria:

- Prior treatment with a VEGF Inhibitor, including bevacizumab and cediranib.

- Poorly controlled hypertension
We found this trial at
46
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Fayetteville, North Carolina 28304
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Hilton Head Island, South Carolina 29926
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3852 Fortune Drive
Layfayette, Indiana 47905
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700 Cajundome Boulevard
Layfayette, Louisiana 70506
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