First Line Metastatic Colorectal Cancer Therapy in Combination With FOLFOX



Status:Completed
Conditions:Colorectal Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - 127
Updated:4/15/2017
Start Date:August 30, 2006
End Date:August 19, 2015

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Trial Summary
Trial Overview
Inclusion Criteria

A Randomised, Double-blind, Multicentre Phase II/III Study to Compare the Efficacy of Cediranib (RECENTIN™, AZD2171) in Combination With 5-fluorouracil, Leucovorin, and Oxaliplatin (FOLFOX), to the Efficacy of Bevacizumab in Combination With FOLFOX in Patients With Previously Untreated Metastatic Colorectal Cancer

The purpose of this study is to see if Cediranib in combination with FOLFOX is effective in
treating metastatic colorectal cancer and to see how it compares with Avastin (Bevacizumab)
in combination with FOLFOX.


Inclusion Criteria:

- Clinical Diagnosis of colon or rectal cancer

- No prior systemic therapy for metastatic disease. Any adjuvant/neoadjuvant
oxaliplatin therapy must have been received >12 months prior to study entry and
adjuvant/neoadjuvant 5-FU must have been received >6 months prior to study entry.

Exclusion Criteria:

- Prior treatment with a VEGF Inhibitor, including bevacizumab and cediranib.

- Poorly controlled hypertension
We found this trial at
46
sites
Clinical Trial Facility in Coos Bay Oregon
Coos Bay, Oregon 97420
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Coos Bay, OR
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Clinical Trial Facility in Abingdon Virginia
Abingdon, Virginia 24210
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Abingdon, VA
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Clinical Trial Facility in Alexandria Louisiana
Alexandria, Louisiana 71301
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Alexandria, LA
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Clinical Trial Facility in Alexandria Virginia
Alexandria, Virginia
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Alexandria, VA
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Clinical Trial Facility in Ann Arbor Michigan
Ann Arbor, Michigan 48109
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from
Ann Arbor, MI
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Clinical Trial Facility in Anniston Alabama
Anniston, Alabama 36207
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from
Anniston, AL
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Clinical Trial Facility in Armidale New South Wales
Armidale, New South Wales 2350
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from
Armidale,
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Clinical Trial Facility in Austin Texas
Austin, Texas 78744
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Austin, TX
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Clinical Trial Facility in Bay Pines Florida
Bay Pines, Florida
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Bay Pines, FL
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Clinical Trial Facility in Birmingham Alabama
Birmingham, Alabama
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from
Birmingham, AL
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Clinical Trial Facility in Bismarck North Dakota
Bismarck, North Dakota 58501
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from
Bismarck, ND
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Clinical Trial Facility in Casa Grande Arizona
Casa Grande, Arizona
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Casa Grande, AZ
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Clinical Trial Facility in Chattanooga Tennessee
Chattanooga, Tennessee
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from
Chattanooga, TN
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Clinical Trial Facility in Cincinnati Ohio
Cincinnati, Ohio
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Cincinnati, OH
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Clinical Trial Facility in Fairfield Connecticut
Fairfield, Connecticut
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from
Fairfield, CT
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Clinical Trial Facility in Fayetteville North Carolina
Fayetteville, North Carolina 28304
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from
Fayetteville, NC
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Clinical Trial Facility in Fort Meyers Florida
Fort Meyers, Florida 33901
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from
Fort Meyers, FL
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Clinical Trial Facility in Fresh Meadows New York
Fresh Meadows, New York 11366
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from
Fresh Meadows, NY
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Clinical Trial Facility in Galesburg Illinois
Galesburg, Illinois 61401
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from
Galesburg, IL
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Clinical Trial Facility in Great Falls Montana
Great Falls, Montana 59405
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Great Falls, MT
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Clinical Trial Facility in Hagerstown Maryland
Hagerstown, Maryland
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from
Hagerstown, MD
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Clinical Trial Facility in Hilton Head Island South Carolina
Hilton Head Island, South Carolina 29926
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from
Hilton Head Island, SC
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Clinical Trial Facility in Hot Springs Arkansas
Hot Springs, Arkansas 71901
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Hot Springs, AR
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Clinical Trial Facility in Knoxville Tennessee
Knoxville, Tennessee 37920
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Knoxville, TN
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Clinical Trial Facility in Layfayette Indiana
3852 Fortune Drive
Layfayette, Indiana 47905
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Layfayette, IN
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Clinical Trial Facility in Layfayette Louisiana
700 Cajundome Boulevard
Layfayette, Louisiana 70506
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Layfayette, LA
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Clinical Trial Facility in Lincoln Nebraska
Lincoln, Nebraska 68515
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from
Lincoln, NE
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Clinical Trial Facility in Middletown Ohio
Middletown, Ohio 45042
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Middletown, OH
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Clinical Trial Facility in Nashville Tennessee
Nashville, Tennessee 37232
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Nashville, TN
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Clinical Trial Facility in New Albany Indiana
New Albany, Indiana 47150
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New Albany, IN
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Clinical Trial Facility in New Bern North Carolina
New Bern, North Carolina 28560
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New Bern, NC
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Clinical Trial Facility in Northport New York
Northport, New York 11768
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Northport, NY
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Clinical Trial Facility in Palm Springs California
Palm Springs, California 92262
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Palm Springs, CA
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Clinical Trial Facility in Park Ridge Illinois
Park Ridge, Illinois 60068
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Park Ridge, IL
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Clinical Trial Facility in Port St Lucie Florida
Port St Lucie, Florida 34952
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Port St Lucie, FL
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Clinical Trial Facility in Port St. Lucie Florida
Port St. Lucie, Florida 34952
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Port St. Lucie, FL
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Clinical Trial Facility in Quincy Illinois
Quincy, Illinois 62301
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Quincy, IL
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Clinical Trial Facility in Rochester New York
Rochester, New York
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Rochester, NY
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Clinical Trial Facility in San Diego California
San Diego, California
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San Diego, CA
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Clinical Trial Facility in St Louis Missouri
St Louis, Missouri
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St Louis, MO
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Clinical Trial Facility in Stamford Connecticut
Stamford, Connecticut 06902
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Stamford, CT
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Clinical Trial Facility in Summit New Jersey
Summit, New Jersey 07901
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Summit, NJ
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Clinical Trial Facility in Tucson Arizona
Tucson, Arizona 85724
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Tucson, AZ
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Clinical Trial Facility in White River Junction Vermont
White River Junction, Vermont
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White River Junction, VT
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Clinical Trial Facility in Ypsilanti Michigan
Ypsilanti, Michigan 48197
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Ypsilanti, MI
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Clinical Trial Facility in Zanesville Ohio
Zanesville, Ohio
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Zanesville, OH
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