Vitamin D Replacement in Nonalcoholic Fatty Liver Disease
| Status: | Completed |
|---|---|
| Conditions: | Gastrointestinal, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/14/2017 |
| Start Date: | January 20, 2012 |
| End Date: | March 10, 2017 |
Vitamin D deficiency is very common in patients with fatty liver disease as evidenced by our
observations in the Metabolic Liver Clinic and that reported by others. We also observed
that patients with more severe fatty liver disease had lower Vitamin D concentrations.
Others have shown that replacing Vitamin D in patients with cirrhosis is effective and even
patients with Vitamin D replete status have lowering of Vitamin D over time if not
supplemented.
One of the measures of liver injury in NAFLD is the plasma concentration of ALT and we will
use this to follow patients as is currently done as standard of care. All patients in the
Metabolic Liver Clinic are being routinely screened for Vitamin D deficiency as standard of
care and treatment is being started with oral supplementation, but there are not
standardized protocols to determine success of therapy. We hypothesize that patients with
NAFLD with low Vitamin D levels will respond appropriately to Vitamin D supplementation for
6 months.
observations in the Metabolic Liver Clinic and that reported by others. We also observed
that patients with more severe fatty liver disease had lower Vitamin D concentrations.
Others have shown that replacing Vitamin D in patients with cirrhosis is effective and even
patients with Vitamin D replete status have lowering of Vitamin D over time if not
supplemented.
One of the measures of liver injury in NAFLD is the plasma concentration of ALT and we will
use this to follow patients as is currently done as standard of care. All patients in the
Metabolic Liver Clinic are being routinely screened for Vitamin D deficiency as standard of
care and treatment is being started with oral supplementation, but there are not
standardized protocols to determine success of therapy. We hypothesize that patients with
NAFLD with low Vitamin D levels will respond appropriately to Vitamin D supplementation for
6 months.
Inclusion Criteria:
- Adults of age 18 or greater
- Diagnosis of fatty liver disease with a low Vitamin D level (< 30 ng/dl) in the past
6 months
- Able to give consent
Exclusion Criteria:
- Those currently receiving Vitamin D supplementation
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