First-In-Human Study of Monoclonal Antibody BMS-986218 by Itself and in Combination With Nivolumab in Patients With Advanced Solid Tumors
| Status: | Recruiting |
|---|---|
| Conditions: | Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 2/2/2019 |
| Start Date: | April 28, 2017 |
| End Date: | March 20, 2021 |
| Contact: | Recruiting sites have contact information. Please contact the sites directly. If there is no contact information, |
| Email: | Clinical.Trials@bms.com |
| Phone: | please email: |
Phase 1/2a First-In-Human Study of BMS-986218 Monoclonal Antibody Alone and in Combination With Nivolumab in Advanced Solid Tumors
The purpose of this study is to determine whether a Monoclonal Antibody both by itself and in
combination with Nivolumab is safe and tolerable in the treatment of advanced solid tumors
combination with Nivolumab is safe and tolerable in the treatment of advanced solid tumors
Inclusion Criteria:
- For more information regarding Bristol-Myers Squibb Clinical Trial participation,
please visit www.BMSStudyConnect.com
- histologic or cytologic confirmation of a solid tumor that is advanced (metastatic,
recurrent and/or unresectable)
- Eastern Cooperative Oncology Group Performance Status of 0 or 1
- Participants must have received, and then progressed, relapsed, or been intolerant to,
all standard treatment regimens with proven survival benefit in the advanced or
metastatic setting according to tumor type, if such a therapy exists
Exclusion Criteria:
- Participants with primary CNS malignancies, or tumors with CNS metastases as the only
site of disease, will be excluded
- Cytotoxic agents, unless at least 4 weeks have elapsed from last dose of prior
anti-cancer therapy and initiation of study therapy
- Prior anti-cancer treatments such as chemotherapy, radiotherapy, hormonal, or
immunotherapy (including anti-PD-1/PD-L1) are permitted
Other protocol defined inclusion/exclusion criteria could apply
We found this trial at
9
sites
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92 2nd St
Hackensack, New Jersey 07601
Hackensack, New Jersey 07601
(201) 996-5900
Phone: 551-996-5900
John Theurer Cancer Center at the Hackensack University Medical Center The mission of the John...
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1275 York Ave
New York, New York 10021
New York, New York 10021
(212) 639-2000
Phone: 281-208-6570
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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3451 Walnut St
Philadelphia, Pennsylvania 19104
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Phone: 215-360-0919
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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