MEDI5083 Alone and in Combination With Durvalumab in Subjects With Select Advanced Solid Tumors.

This is a global Phase 1, first-time-in-human, multicenter, open-label, dose-escalation and
dose-expansion study of MEDI5083 alone and in combination with durvalumab

Inclusion Criteria:

1. Age ≥ 18 years at the time of screening or age of consent according to local law

2. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 or 1

3. Histologically or cytologically confirmed metastatic or recurrent tumor types

4. Subjects who have received prior immunotherapy may be eligible

5. Subjects must have at least one measurable lesion

6. Consent to provide archival tumor tissue and pre/on-treatment biopsies

7. Adequate organ and marrow function

8. Consent to use one highly effective method of contraception

Exclusion Criteria:

1. Receipt of any systemic anticancer therapy within 28 days prior to the first dose of
MEDI5083

2. Concurrent enrollment in another clinical study

3. Active/prior autoimmune of inflammatory disorders

4. History of immunodeficiency, solid organ transplant, or tuberculosis

5. Known allergy/hypersensitivity to drug or components

6. Untreated central nervous system (CNS) metastatic disease, leptomeningeal disease, or
cord compression

7. Current or prior use of immunosuppressive medication within 14 days prior to the first
dose of MEDI5083