Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism (IHH)



Status:Terminated
Conditions:Endocrine, Endocrine
Therapuetic Areas:Endocrinology
Healthy:No
Age Range:18 - Any
Updated:4/19/2017
Start Date:May 2010
End Date:September 1, 2010

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

Effect of Varying Testosterone Levels on Insulin Sensitivity in Men With Idiopathic Hypogonadotropic Hypogonadism

The investigators are doing this research study to look at the relationship between
testosterone (the main sex hormone in men) and insulin (the hormone that controls blood
sugar levels) in men with Idiopathic Hypogonadotropic Hypogonadism (IHH).

The investigators hypothesize that normalizing testosterone levels in men with IHH enhances
insulin sensitivity, reduces visceral fat, increases lean body mass, and improves the lipid
profile.


Inclusion Criteria:

- Diagnosis of idiopathic hypogonadotropic hypogonadism or Kallmann Syndrome

- mean testosterone level less than 300 ng/dl

- stable weight for the previous 3 months (no weight change greater than or equal to 10
lbs)

- normal serum TSH

- normal serum prolactin levels

Exclusion Criteria:

- Type 2 diabetes mellitus

- history of diabetes in parents

- sleep apnea

- bleeding disorder

- seeking fertility

- 2 or more cardiovascular risk factors: smoking, hypertension, diabetes,
dyslipidemias, family history of cardiovascular disease before age 60.

- history of previous cardiovascular event: myocardial infarction, unstable angina,
cerebro-vascular accident.

- illicit drug use/alcohol use (>4 drinks per day)
We found this trial at
1
site
Massachusetts General Hospital
185 Cambridge Street
Boston, Massachusetts 02114
617-724-5200
?
mi
from
Boston, MA
Click here to add this to my saved trials