A Study of OMP-313M32 in Subjects With Locally Advanced or Metastatic Solid Tumors

This is an open-label, Phase 1a/b dose escalation study of OMP-31M32 administered as a single
agent or in combination with nivolumab to evaluate the safety, tolerability pharmacokinetics,
and pharmacodynamics in patients with locally advanced or metastatic solid tumors. This study
consists of a screening period, a treatment period and a post-treatment follow-up period in
which patients will be followed for survival for up to 2 years. Subjects will be enrolled in
two stages in the Phase 1a (dose escalation and expansion) and one stage in the Phase 1b
(dose escalation).

Inclusion Criteria:

1. Histologic documentation of locally advanced, recurrent or metastatic solid malignancy
that has progressed and standard therapy has been ineffective or intolerable. Phase 1b
subjects must also have experienced disease progression after treatment with an anti
PD-1 or PDL-1 agent.

2. Ability to understand the willingness and to sign a written informed consent document

3. Age >/= 18 years

4. Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1

5. Life expectancy >/=12 weeks

6. Measurable disease per response evaluation criteria in solid tumors.

7. Adequate hematologic and organ function

8. For women of childbearing potential and men with partners of childbearing potential,
agreement (by patient and/or partner) to use two effective forms of contraception from
study entry through at least 6 months after the termination visit.

Exclusion Criteria:

1. Anti-cancer therapy, including chemotherapy, hormonal therapy, or radiotherapy, within
3 weeks or 5 half lives, whichever is shorter, prior to initiation of study treatment

2. Active autoimmune disease or a history of severe autoimmune disease or syndrome

3. History of severe allergic, anaphylactic, or other hypersensitivity reactions to
chimeric or humanized antibodies or fusion proteins.

4. Inability to comply with study and follow-up procedures.

5. Pregnancy, lactation, or breastfeeding women.

6. Significant cardiovascular disease, such as New York Heart Association cardiac disease
(Class II or greater), myocardial infarction within the previous 3 months, unstable
arrhythmias, or unstable angina.

7. Known clinically significant liver disease,

8. Major surgical procedure within 28 days prior to initiation of study treatment or
anticipation of need for a major surgical procedure during the course of the study.

9. Any other diseases, metabolic dysfunction, physical examination finding, or clinical
laboratory finding giving reasonable suspicion of a disease or condition that
contraindicates the use of an investigational drug or that may affect the
interpretation of the results or render the patient at high risk from treatment
complications.