Lymphatic and Systemic Immunity Changes in Post-radiation Lymphedema Development

Inclusion Criteria:

- Participants must be at least 18 years of age

- Participants must have been clinically diagnosed with breast cancer and scheduled for
axillary lymph node dissection (ALND) and radiation treatment at MD Anderson
(receiving chemotherapy, mastectomy or breast-conserving surgery, ALND (>10 nodes) and
radiation treatment for breast cancer, identified by Drs. Mittendorf and Shaitelman of
the Nellie B. Connally Breast Cancer Center at MD Anderson)

- Ambulatory and possessing all four limbs

- No prior radiation therapy

- Negative urine pregnancy test within 36 hours prior to study drug administration, if
of childbearing potential

- Females participants must complete the Female Enrollment Form. Childbearing potential
participants must agree to use one of the medically accepted forms of contraception
for a period of one month after study participation. Female participants who meet the
criteria for non-childbearing will still complete the Female Enrollment Form, but are
not restricted to the use of contraception following study participation.

Exclusion Criteria:

- Participants with a known or suspected allergy to iodine

- Participants who are breastfeeding, pregnant or trying to become pregnant

- Severe underlying chronic illness or disease (other than breast cancer)

- Participants not capable of keeping moderately still for the imaging portion of the
study session (~1 hour for imaging)