Study of Recovery of Strength After Surgery Comparing Two Different Medications for Reversal of Muscle Relaxant
Status: | Recruiting |
---|---|
Healthy: | No |
Age Range: | 18 - Any |
Updated: | 4/4/2019 |
Start Date: | April 7, 2017 |
End Date: | April 2019 |
Contact: | Florence Grant, MD |
Email: | moses-gf@mskcc.org |
Phone: | 212-639-8829 |
Randomized Controlled Assessor Blinded Clinical Trial of Sugammadex Versus Neostigmine /Glycopyrrolate for Reversal of Rocuronium Induced Neuromuscular Blockade: Time to Discharge From Post Anesthesia Care Unit and Patient Satisfaction With Recovery
The purpose of this study is to compare two different medications (neostigmine/glycopyrrolate
and sugammadex) to see if one drug improves patient comfort regarding the return of muscle
strength after surgery.
and sugammadex) to see if one drug improves patient comfort regarding the return of muscle
strength after surgery.
Inclusion Criteria:
- Adult patients age 18 years of age or greater who are capable of giving consent
- Undergoing surgical procedures of expected length 6 = hours requiring NMB
Exclusion Criteria:
- Pregnancy
- History of documented anaphylaxis or contraindication to any of the study medications
- Active coronary disease with a positive cardiac stress test
- History of severe chronic obstructive pulmonary disease (COPD) defined as an FEV1 <
50% of predicted
- Serum Creatinine >/= 2.0 mg/dL
- Severe hepatic dysfunction accompanied by coagulopathy
- Definition:
- Known liver Disease AND
- INR > 1.5 (except for patients on anticoagulants) AND
- Platelet count <100,00/ul without other obvious cause
- Chronic sustained release opioid for > 2 weeks duration pre op (in the 30 days prior
to surgery)
- Use of toremifene
- Significant cognitive impairment or documented psychologic impairment
- Myasthenia gravis or other neuromuscular disease
- Patients who are not eligible for standard anesthetic induction, eg, those needing
rapid sequence induction or awake fiberoptic bronchial intubation.
- American Society of Anesthesiologists (ASA) Status > 3
We found this trial at
4
sites
1275 York Ave
New York, New York 10021
New York, New York 10021
(212) 639-2000
Phone: 212-639-8829
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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136 Mountainview Boulevard
Basking Ridge, New Jersey 07920
Basking Ridge, New Jersey 07920
Phone: 212-639-8829
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650 Commack Rd
Commack, New York 11725
Commack, New York 11725
(631) 623-4000
Phone: 212-639-8829
Memorial Sloan-Kettering Cancer Center at Commack Memorial Sloan Kettering Cancer Center - the world's oldest...
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Click here to add this to my saved trials