Live Donors for Kidney Transplants
| Status: | Completed |
|---|---|
| Conditions: | Renal Impairment / Chronic Kidney Disease |
| Therapuetic Areas: | Nephrology / Urology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/5/2019 |
| Start Date: | May 17, 1999 |
| End Date: | May 30, 2014 |
Live Donor Renal Donation for Allotransplantation
On a yearly basis there are approximately 12,000 kidney transplants in the United States.
Presently there are approximately 40,000 patients awaiting a transplant with only 5,000
available donors. Due to the obvious difference between organ supply and demand, live donors
have become a standard source of kidneys for transplantation.
Research has proven that kidneys from living donors are superior to cadaveric donors (kidneys
harvested from a deceased individual). Kidneys from living donors are not exposed to
extremely low temperature that could increase post-operative problems. They are less likely
to experience rejection and there is a decreased likelihood that a patient will have to
undergo post-operative dialysis.
The objective of this study is to promote the enrollment of healthy individuals to serve as
kidney donors for patients undergoing research kidney transplantation at the NIH. Potential
donors will be screened to make sure they are able to survive with a single kidney without
significant medical risk. Additional tests will be taken to establish compatibility with the
recipient. Compatible donors will be evaluated to determine which kidney is suitable for
transplantation. Both the donation and transplantation procedure will be conducted on the
same day. Appropriate post-operative care and follow-up will be provided at the Clinical
Center....
Presently there are approximately 40,000 patients awaiting a transplant with only 5,000
available donors. Due to the obvious difference between organ supply and demand, live donors
have become a standard source of kidneys for transplantation.
Research has proven that kidneys from living donors are superior to cadaveric donors (kidneys
harvested from a deceased individual). Kidneys from living donors are not exposed to
extremely low temperature that could increase post-operative problems. They are less likely
to experience rejection and there is a decreased likelihood that a patient will have to
undergo post-operative dialysis.
The objective of this study is to promote the enrollment of healthy individuals to serve as
kidney donors for patients undergoing research kidney transplantation at the NIH. Potential
donors will be screened to make sure they are able to survive with a single kidney without
significant medical risk. Additional tests will be taken to establish compatibility with the
recipient. Compatible donors will be evaluated to determine which kidney is suitable for
transplantation. Both the donation and transplantation procedure will be conducted on the
same day. Appropriate post-operative care and follow-up will be provided at the Clinical
Center....
This protocol is designed to facilitate the enrollment of healthy individuals to serve as
renal allograft donors for subjects undergoing protocol renal transplantation at the NIH.
Donation will be allowed for altruistic purposes only.
renal allograft donors for subjects undergoing protocol renal transplantation at the NIH.
Donation will be allowed for altruistic purposes only.
- INCLUSION CRITERIA:
Willingness to donate without evidence of secondary gain, coercion, or conflict of
interest.
Age greater than or equal to 18 years
ABO compatible with recipient
Normal renal function with a 24hr creatinine clearance greater than 80ml/min/1.73m(2).
Willingness and legal ability to give informed consent
Recipient is enrolled in a NIH protocol for transplantation or has been established as a
candidate for receipt of an altruistic or paired donation through the Washington Regional
Organ Procurement Agency donor program.
EXCLUSION CRITERIA:
Hypertension
Pregnancy
History of stroke
Active tuberculosis
History of active malignancies except basal cell carcinoma of the skin.
Major anticipated illness or organ failure incompatible with survival after nephrectomy
Functionally significant coronary artery disease.
Active kidney stones
Proteinuria (greater than 250mg/24hr)
We found this trial at
1
site
9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
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