HIV-to-HIV Transplant at MGH

This is an observational study designed to evaluate safety and outcomes of solid organ
transplantation in HIV+ recipients of HIV+ deceased donors. This study will evaluate overall
survival and graft survival compared to transplantation with an HIV- organ.

In addition the study will assess potential complications of organ transplant using HIV+
deceased donors - including but not limited to - HIV superinfection, incidence and severity
of graft rejection, recurrence of HIV-associated nephropathy, incidence of bacterial
infections, and opportunistic infections.

Inclusion Criteria:

1. Participant is able to understand and provide informed consent

2. Participant meets standard listing criteria for transplant.

3. Documented HIV infection (by any licensed ELISA and confirmation by Western Blot,
positive HIV ab IFA, or documented history of detectable HIV-1 RNA).

4. Participant is ≥ 18 years old.

5. Opportunistic Complications: None or previous history of protocol allowed
opportunistic infections or neoplasms with appropriate acute and maintenance therapy
and no evidence of active disease.

6. Participant CD4+ T-cell count is >/= 200/μL prior to renal transplant or for liver
transplant is >/= 100/μL within 16 weeks prior to transplant and no history of
opportunistic infection (OI); or ≥200 μL if history of OI is present.

7. Participant HIV-1 RNA < 50 copies/mL (by any FDA-approved assay performed in
CLIA-approved laboratory), in the 26 weeks prior to transplant. Non-consecutive viral
"blips" between 50-400 copies RNA/mL will be allowed.

8. Antiretroviral therapy: To avoid drug interactions, ritonavir or cobicistat-containing
regimens are not recommended, unless in the opinion of the HIV/Transplant Infectious
Disease team there is no alternative regimen expected to control HIV replication.

9. Participant is willing to use PCP, herpes virus and fungal prophylaxis as indicated.

Exclusion Criteria:

1. Participant has concomitant conditions that, in the judgment of the investigators,
would preclude transplantation or immunosuppression.

2. Opportunistic Complication History: Any history of progressive multifocal
leukoencephalopathy (PML), chronic intestinal cryptosporidiosis of > 1 month duration,
or primary CNS lymphoma.

3. Participant has a history of any neoplasm except for the following: resolved kaposi's
sarcoma, in situ anogenital carcinoma, adequatelytreated basal or squamous cell
carcinoma of the skin, solid tumors (except primary CNS lymphoma) treated with
curative therapy and disease free for more than 5 years. History of renal cell
carcinoma requires disease free state for 2 years. History of leukemia and
disease-free duration will be per site policy.

4. Participant is pregnant or breastfeeding. Note: Participants who become pregnant
post-transplant will continue to be followed in the study and will be managed per
clinical practice. Women that become pregnant should not breastfeed.