Validation of Predictors of OAC Initiation Using EMR Data



Status:Completed
Conditions:Atrial Fibrillation
Therapuetic Areas:Cardiology / Vascular Diseases
Healthy:No
Age Range:18 - Any
Updated:3/24/2019
Start Date:February 28, 2017
End Date:May 9, 2017

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Trial Summary
Trial Overview
Inclusion Criteria

Validation of Predictors for Oral Anticoagulant Medication Choice Using EMR Data

The objectives of this study are, first, to identify select clinical covariates from
electronic medical records (EMR) that might be associated with initiation of oral
anticoagulant medications (dabigatran or warfarin) in patients with non-valvular atrial
fibrillation (NVAF) at risk for stroke; second, to quantify the association between EMR-based
clinical characteristics and patterns of insurance claims; third, to assess the potential for
unmeasured confounding in dabigatran vs warfarin comparative effectiveness and safety studies
based on administrative claims databases.


Inclusion Criteria:

- First dispensing of warfarin or dabigatran between October 2010 and December 2014

- Diagnosis of atrial fibrillation

- ≥ 12 months enrolment in the database preceding the date of the first dispensing

- Age ≥ 18

- Congestive Heart Failure, Hypertension, Age > 75, Diabetes Mellitus, Prior Stroke or
Transient Ischemic Attack, Vascular Disease (CHA2DS2-VASc) score ≥ 1

Exclusion Criteria:

- Prior use of oral anticoagulation

- Evidence of valvular atrial fibrillation

- Missing or ambiguous age or sex information

- Patients with a nursing home stay during baseline
We found this trial at
1
site
Brigham and Women's Hosp
75 Francis street
Boston, Massachusetts 02115
(617) 732-5500
Phone: 617-278-0930
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
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