Delivering a Diuretic Into the Liver Artery Followed by Plugging up the Artery to Starve Out Liver Cancer Cells
| Status: | Recruiting |
|---|---|
| Conditions: | Liver Cancer, Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 3/6/2019 |
| Start Date: | April 5, 2017 |
| End Date: | April 5, 2020 |
| Contact: | Hooman Yarmohammadi, MD |
| Email: | yarmohah@mskcc.org |
| Phone: | 212-639-2234 |
Phase I/II Study of Transarterial Hepatic Embolization With Bumetanide in Unresectable Hepatocellular Carcinoma
The purpose of this study is to test the safety of Bumetanide , at different doses to find
out what effects, if any, it has on people who undergo tumor TAE as part of their regular
care. Bumetanide is a commonly used medication to reduce the amount of water in the body.
out what effects, if any, it has on people who undergo tumor TAE as part of their regular
care. Bumetanide is a commonly used medication to reduce the amount of water in the body.
Inclusion Criteria:
- Patients with diagnoses of HCC according to European Association for the Study of
Liver disease (EASL) criteria for diagnosis (See Appendix 1). Regional lymphadenopathy
will be allowed.
- Any virus status accepted (e.g. Hepatitis C etc.)
- Any prior liver treatment
- Patients within unresectable HCC
- At least 18 years old
- ECOG performance status 0 or 1
- Radiographically measurable disease per mRECIST 1.1
- Meets standard of care to undergo embolization
Exclusion Criteria:
- Women who are pregnant or lactating
- Documented hypersensitivity to bumetanide or sulfonamides
- Patients with resectable HCC
- High risk for post-embolization hepatic failure:
°Child's C cirrhosis
°> 80% liver involvement by tumor
- Contraindication to angiography/embolization including:
- Patients cannot receive contrast:
- Severe allergic reaction to contrast despite premedication
- Poor renal function not on dialysis
- Other, based on judgment of the investigator
- ECOG score 2
- Main portal vein tumor thrombus
- BCLC D = patients with distant metastasis
We found this trial at
6
sites
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136 Mountainview Boulevard
Basking Ridge, New Jersey 07920
Basking Ridge, New Jersey 07920
Phone: 212-639-2234
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500 Westchester Avenue
Harrison, New York 10604
Harrison, New York 10604
Phone: 212-639-2234
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1275 York Ave
New York, New York 10021
New York, New York 10021
(212) 639-2000
Principal Investigator: Hooman Yarmohammadi, MD
Phone: 212-639-2234
Memorial Sloan Kettering Cancer Center Memorial Sloan Kettering Cancer Center — the world's oldest and...
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