TLR4 Polymorphisms and Risk of Skin Cancer



Status:Active, not recruiting
Conditions:Skin Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:50 - Any
Updated:11/4/2018
Start Date:February 2, 2009
End Date:September 27, 2019

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Trial Summary
Trial Overview
Inclusion Criteria

TLR4 Polymorphisms and Predisposition for Skin Cancer Development

Toll-like receptors (TLRs) play a key role in the innate immune system. Toll-like receptor-4
(TLR4) in particular, appears to play a role in susceptibility to cancer. Of 44 identified
SNPs (small nucleotide polymorphisms) in TLR4, the most common is an A-G substitution at
nucleotide position +896, downstream of the cDNA start codon, a missense mutation which leads
to an amino acid substitution Asp299Gly in the third exon of the TLR4 gene. Pre-clinical
studies from our laboratory have shown an association of TLR4 with ultraviolet radiation
induced skin cancer. Hence, in this study we will assess the pattern of TLR4 polymorphisms
and susceptibility to skin cancer.


Inclusion Criteria:

- Male or female over the age of 50

- Fitzpatrick skin type I-IV

Exclusion Criteria:

- Tumor types other than basal cell carcinoma, squamous cell carcinoma and melanoma

- Chronic immunosuppression due to transplant antirejection regimen or HIV/AIDS

- Nevoid basal cell carcinoma syndrome, Cowden's syndrome, xeroderma pigmentosum or
other syndrome with skin-cancer predisposition

- Known exposure to arsenic or ionizing radiation
We found this trial at
1
site
Kirklin Clinic
Birmingham, Alabama 35233
?
mi
from
Birmingham, AL
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