Case-Control Study of Pesticides and Childhood Leukemia
| Status: | Completed |
|---|---|
| Conditions: | Blood Cancer, Leukemia |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | Any - 14 |
| Updated: | 12/13/2018 |
| Start Date: | October 30, 2001 |
A Case-Control Study of Pesticides and Childhood Leukemia
Childhood leukemia is the most common type of childhood cancer and its etiology is largely
unknown. Most case-control studies of childhood leukemia have reported elevated risks among
children whose parents were occupationally exposed to pesticides or who used pesticides in
the home or garden. Investigators at the University of California at Berkeley (UCB) conducted
a case-control study of childhood leukemia in 35 counties in the San Francisco Bay area and
the agricultural Central Valley of California. A major focus of the UCB study is to evaluate
whether household or occupational exposure to pesticides increases the risk of childhood
leukemia. Our collaboration provided additional funding to collect carpet dust samples for
the measurement of pesticides and other chemicals. For 470 participants, we attempted to
collect carpet dust using a special high volume small surface sampler (HVS3) vacuum and by
taking dust from participants vacuum cleaner. As of July 2006, dust samples will be collected
only from participant's vacuum cleaner. Samples were collected at a home visit approximately
3-6 months after the first in-person interview. We will also provide support for mapping of
the crops (i.e., determining crop field boundaries and crop species) within 1200 meters (3/4
mile) of residences so that the residential proximity to agricultural fields treated with
pesticides can be determined. We will conduct the epidemiologic analysis of pesticide and
other chemical levels in carpet dust and risk of childhood leukemia. We will also evaluate
whether residential proximity to agricultural pesticide use is associated with risk of
leukemia. Further, we will conduct an Exposure Pilot Study that will include a subset of the
study population. Two components of the Pilot Study will evaluate how well a used vacuum bag
and a window sill wipe predict pesticide and other chemical concentrations in carpet dust
samples collected with the more complicated HVS3 vacuum method. The third component will
compare pesticides detected in carpet dust with pesticides predicted by geographic proximity
to agriculture.
unknown. Most case-control studies of childhood leukemia have reported elevated risks among
children whose parents were occupationally exposed to pesticides or who used pesticides in
the home or garden. Investigators at the University of California at Berkeley (UCB) conducted
a case-control study of childhood leukemia in 35 counties in the San Francisco Bay area and
the agricultural Central Valley of California. A major focus of the UCB study is to evaluate
whether household or occupational exposure to pesticides increases the risk of childhood
leukemia. Our collaboration provided additional funding to collect carpet dust samples for
the measurement of pesticides and other chemicals. For 470 participants, we attempted to
collect carpet dust using a special high volume small surface sampler (HVS3) vacuum and by
taking dust from participants vacuum cleaner. As of July 2006, dust samples will be collected
only from participant's vacuum cleaner. Samples were collected at a home visit approximately
3-6 months after the first in-person interview. We will also provide support for mapping of
the crops (i.e., determining crop field boundaries and crop species) within 1200 meters (3/4
mile) of residences so that the residential proximity to agricultural fields treated with
pesticides can be determined. We will conduct the epidemiologic analysis of pesticide and
other chemical levels in carpet dust and risk of childhood leukemia. We will also evaluate
whether residential proximity to agricultural pesticide use is associated with risk of
leukemia. Further, we will conduct an Exposure Pilot Study that will include a subset of the
study population. Two components of the Pilot Study will evaluate how well a used vacuum bag
and a window sill wipe predict pesticide and other chemical concentrations in carpet dust
samples collected with the more complicated HVS3 vacuum method. The third component will
compare pesticides detected in carpet dust with pesticides predicted by geographic proximity
to agriculture.
Childhood leukemia is the most common type of childhood cancer and its etiology is largely
unknown. Most case-control studies of childhood leukemia have reported elevated risks among
children whose parents were occupationally exposed to pesticides or who used pesticides in
the home or garden. Investigators at the University of California at Berkeley (UCB) conducted
a case-control study of childhood leukemia in 35 counties in the San Francisco Bay area and
the agricultural Central Valley of California. A major focus of the UCB study was to evaluate
whether household or occupational exposure to pesticides increases the risk of childhood
leukemia. Our collaboration provided additional funding to collect carpet dust samples for
the measurement of pesticides and other chemicals. For 470 participants, we attempted to
collect carpet dust using a special high volume small surface sampler (HVS3) vacuum and by
taking dust from participants vacuum cleaner. As of July 2006, dust samples were collected
only from participant's vacuum cleaner. Samples were collected at a home visit approximately
3-6 months after the first in-person interview. We also provided support for mapping of the
crops (i.e., determining crop field boundaries and crop species) within 1200 meters (3/4
mile) of residences so that the residential proximity to agricultural fields treated with
pesticides can be determined. We will conduct the epidemiologic analysis of pesticide and
other chemical levels in carpet dust and risk of childhood leukemia. We will also evaluate
whether residential proximity to agricultural pesticide use is associated with risk of
leukemia. Further, we will conduct an Exposure Pilot Study that will include a subset of the
study population. Two components of the Pilot Study will evaluate how well a used vacuum bag
and a window sill wipe predict pesticide and other chemical concentrations in carpet dust
samples collected with the more complicated HVS3 vacuum method. The third component will
compare pesticides detected in carpet dust with pesticides predicted by geographic proximity
to agriculture.
unknown. Most case-control studies of childhood leukemia have reported elevated risks among
children whose parents were occupationally exposed to pesticides or who used pesticides in
the home or garden. Investigators at the University of California at Berkeley (UCB) conducted
a case-control study of childhood leukemia in 35 counties in the San Francisco Bay area and
the agricultural Central Valley of California. A major focus of the UCB study was to evaluate
whether household or occupational exposure to pesticides increases the risk of childhood
leukemia. Our collaboration provided additional funding to collect carpet dust samples for
the measurement of pesticides and other chemicals. For 470 participants, we attempted to
collect carpet dust using a special high volume small surface sampler (HVS3) vacuum and by
taking dust from participants vacuum cleaner. As of July 2006, dust samples were collected
only from participant's vacuum cleaner. Samples were collected at a home visit approximately
3-6 months after the first in-person interview. We also provided support for mapping of the
crops (i.e., determining crop field boundaries and crop species) within 1200 meters (3/4
mile) of residences so that the residential proximity to agricultural fields treated with
pesticides can be determined. We will conduct the epidemiologic analysis of pesticide and
other chemical levels in carpet dust and risk of childhood leukemia. We will also evaluate
whether residential proximity to agricultural pesticide use is associated with risk of
leukemia. Further, we will conduct an Exposure Pilot Study that will include a subset of the
study population. Two components of the Pilot Study will evaluate how well a used vacuum bag
and a window sill wipe predict pesticide and other chemical concentrations in carpet dust
samples collected with the more complicated HVS3 vacuum method. The third component will
compare pesticides detected in carpet dust with pesticides predicted by geographic proximity
to agriculture.
- INCLUSION CRITERIA:
All cases and controls were selected from participants in the UCB case-control study who
have completed the Tier I interview.
Study population is limited to children.
All races and ethnicities will be included in the study.
Tier I:
The cases eligible for participation in Tier I of the UCB study of all newly diagnosed
cases of childhood leukemia 0-14 years old resident in 35 counties in San Francisco Bay
Area and the Central Valley
Further inclusion criteria are no prior cancer diagnosis and at least one English or
Spanish speaking parent.
Tier II:
Tier II participants will be selected from cases and controls that complete the Tier I
interview. Cases (and their match controls), aged 0-7, diagnosed from December 1, 1999
through 2003, and who still reside at the home where they were living ate the diagnosis
date, will be eligible for the Tier II interview.
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