NSAID Use in Postpartum Hypertensive Women
| Status: | Terminated |
|---|---|
| Conditions: | High Blood Pressure (Hypertension) |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 14 - 50 |
| Updated: | 11/2/2018 |
| Start Date: | March 15, 2017 |
| End Date: | October 8, 2017 |
Women who have the diagnosis of hypertension (pre-pregnancy and pregnancy induced) and
deliver an infant via vaginal delivery will be placed into two groups in the postpartum
period. One group will receive Ibuprofen for pain control and the other group will be given
Tylenol. Blood pressures during the postpartum period will then be collected and compared in
order to see if NSAIDs use increases blood pressure.
deliver an infant via vaginal delivery will be placed into two groups in the postpartum
period. One group will receive Ibuprofen for pain control and the other group will be given
Tylenol. Blood pressures during the postpartum period will then be collected and compared in
order to see if NSAIDs use increases blood pressure.
The patients who have a vaginal delivery and have the diagnosis of hypertension in pregnancy
will be randomized to either Ibuprofen use or acetaminophen use during the postpartum period.
Standard blood pressure monitoring in the postpartum period will be followed to help
determine if there is a significant rise in the women who use NSAIDS in the postpartum period
versus those that use acetaminophen.
Groups will be divided into women with chronic hypertension, women with chronic hypertension
with superimposed preeclampsia, women with preeclampsia without severe features, women with
preeclampsia with severe features, women with gestational hypertension without severe range
blood pressures, and women with gestational hypertension with severe range blood pressures.
Recruitment will last 36 months. Patients will be monitored during their postpartum stay
(typical 2 days) with blood pressure measurements. An additional 12 months will be needed for
data analysis and publication.
will be randomized to either Ibuprofen use or acetaminophen use during the postpartum period.
Standard blood pressure monitoring in the postpartum period will be followed to help
determine if there is a significant rise in the women who use NSAIDS in the postpartum period
versus those that use acetaminophen.
Groups will be divided into women with chronic hypertension, women with chronic hypertension
with superimposed preeclampsia, women with preeclampsia without severe features, women with
preeclampsia with severe features, women with gestational hypertension without severe range
blood pressures, and women with gestational hypertension with severe range blood pressures.
Recruitment will last 36 months. Patients will be monitored during their postpartum stay
(typical 2 days) with blood pressure measurements. An additional 12 months will be needed for
data analysis and publication.
Inclusion Criteria:
- vaginal delivery
- diagnosis of chronic hypertension, chronic hypertension with superimposed preeclampsia
- preeclampsia without severe features
- preeclampsia with severe features gestational hypertension without severe range blood
pressures
- gestational hypertension with severe range blood pressures
- singleton pregnancies
Exclusion Criteria:
- Cesarean Delivery
- no diagnosis of hypertensive disorder
- chronic or acute renal disease
- allergy to ibuprofen or acetaminophen
- lupus
- multiple order pregnancies (twins, triplets)
- Narcotic addiction/ in treatment for substance abuse/ current prescription drug user/
current use of illegal drugs
We found this trial at
1
site
Click here to add this to my saved trials
