Multi-Parametric Quantitative MR Imaging in Evaluation of Brain Tumors

The primary objective of this study is to 1) evaluate the utility of quantitative MRI imaging
including 3D-MRF in differentiating among different brain tumors and differentiating
recurrent brain tumor (TR) from treatment effects

Secondary objectives include evaluating the correlation between quantitative MRI imaging with
histopathological characteristics and genetic markers in pre-therapy setting and with
treatment response and clinical outcomes in post treatment setting.

GROUP 1: All patients with newly diagnosed intra-axial brain neoplasms undergo volumetric MRI
study with contrast for surgical planning or clinical diagnosis. Diffusion, diffusion tensor
imaging and perfusion imaging are often performed as a part of standard clinical imaging. In
addition to these acquisitions, the research 3D-MRF acquisition through the entire tumor will
be acquired. The imaging parameters will be correlated individually and in combination with
biopsy/ resection outcomes.

GROUP 2: All patients with brain tumors who present at post therapy follow up with imaging
progression undergo serial imaging as a part of clinical care. The research 3D-MRF
acquisitions will be added to these clinical scans. All the quantitative parameters will be
evaluated individually and in combination to differentiate post treatment changes from tumor
recurrence.

Inclusion Criteria:

- Diagnosis of intra-axial brain tumor at initial diagnosis or patients with known
treated brain tumors on follow-up with concern for imaging progression

- Ability to understand and the willingness to sign a written informed consent document,
or, in cases where the patient may have cognitive impairment, consent by a legal
authorized representative or power of attorney

Exclusion Criteria:

- Patients with ferromagnetic or otherwise non-MRI compatible aneurysm clips.

- The presence of an implanted pacemaker or implanted defibrillator device.

- Patients with contraindications for MRI due to embedded foreign metallic objects.
Bullets, shrapnel, metalwork fragments, or other metallic material adds unnecessary
risk to the patient.

- Pregnancy. Regular clinical practice already excludes pregnant patients from
gadolinium contrast.

- Implanted medical device not described above that is not MRI-compatible.

- Known history of severe claustrophobia.

- Prisoners and members of other vulnerable populations will be excluded from this
study. The subject selection population will not regularly include prisoners and other
vulnerable population members as these populations will not provide any additional
unique information to or uniquely benefit from the study. Non-English speaking
population will be excluded from the study due to lack of sufficient resources to pay
for translator and interpreter services.

- Minors will be excluded.