Identification of Biomarkers for Patients With Vascular Anomalies

While vascular anomalies are rare diseases, they can be life-threatening and devastating to
affected children and their families. Advances in diagnosis, monitoring and therapies will be
significantly improved if non-invasive biomarkers that are sensitive and specific can be
identified. Obtaining a tissue biopsy to help in diagnosis can actually worsen the disease
and so identification of specific blood biomarkers is highly desirable. Studies will measure
angiogenic factors in serum and plasma samples at baseline and on therapy. Tissue removed
during surgical resection or blood removed prior to sclerotherapy will be used to obtain
cells and tissue for the assessment of where biomarkers are coming from and to identify
disease-causing pathways for new therapeutic targeting.

Inclusion Criteria:

- Any patient having labs drawn as standard of care will have blood drawn for the study
if consented/ assented.

- All patients who are undergoing a surgical procedure or sclerotherapy are currently
consented for participation in the tissue bank.

Exclusion Criteria: