Comparison Study Between Cefdinir & Amoxicilline/Clavulanate in Acute Sinusitis and Assessment of Quality of Life

The purpose if this investigation is to evaluate the rate of improvement ub Quality of LIfe
(QOL) in two different medications, a 10-day course of Cefdinir 300 mg PO BID versus a
10-day course of Amoxicillin/Clavulanate 1000 mg/62.5 mg XR BID, in the treatment of acute
bacterial sinusitis.

Inclusion Criteria:

- Male and female outpatient adults greater than 18 years old fulfilling the case
definition for acute bacterial sinusitis

- Case definition includes clinical signs and symptoms, radiographic findings and
collection of purulent material from the sinus

Exclusion Criteria:

- Symptoms less than 7 days and more than 3 weeks

- History of sinus surgery within 3 months

- History of frequent sinus infections (more than 2 episodes within the last 6 months)

- History of kidney and liver disease

- Pregnant and nursing women

- Pre-existing disease that could predispose to sinus infections (cystic fibrosis or
nasal polyps

- Immunosuppressed patients

- History of allergy to either drug. Patients with a documented history of allergies to
either penicillin or cephalosporins will be excluded.