Mapping Electrogram Morphology Recurrence for Atrial Fibrillation Ablation
| Status: | Recruiting |
|---|---|
| Conditions: | Atrial Fibrillation |
| Therapuetic Areas: | Cardiology / Vascular Diseases |
| Healthy: | No |
| Age Range: | 21 - Any |
| Updated: | 1/19/2019 |
| Start Date: | April 4, 2017 |
| End Date: | December 31, 2019 |
| Contact: | Raul Mitrani, MD |
| Email: | rmitrani@med.miami.edu |
| Phone: | 305-243-5070 |
The overall goal of this project is to test the feasibility of performing real-time
electrogram morphology recurrence (EMR) mapping in patients with persistent atrial
fibrillation (AF) to locate areas of high electrogram morphology recurrence rate. The
Investigator believe that the EMR mapping can be integrated into cardiac mapping and used to
identify potential sites for ablation. Furthermore, this study could help demonstrate the
efficacy of this technology's ability to terminate or slow AF.
The Investigator will test this technology on ten subjects undergoing a second ablation
procedure. The Investigator will map the AF utilizing the EMR to indicate locations of stable
activity and ablate the area. The Investigator believes that the study could produce acute AF
termination or AF cycle length slowing. In addition to testing the real-time electrogram
morphology recurrence mapping, the study would also like to determine the acute effects of
radiofrequency ablation of areas of high recurrence rates and determine long term freedom
from AF following ablation of areas of high recurrence rates.
electrogram morphology recurrence (EMR) mapping in patients with persistent atrial
fibrillation (AF) to locate areas of high electrogram morphology recurrence rate. The
Investigator believe that the EMR mapping can be integrated into cardiac mapping and used to
identify potential sites for ablation. Furthermore, this study could help demonstrate the
efficacy of this technology's ability to terminate or slow AF.
The Investigator will test this technology on ten subjects undergoing a second ablation
procedure. The Investigator will map the AF utilizing the EMR to indicate locations of stable
activity and ablate the area. The Investigator believes that the study could produce acute AF
termination or AF cycle length slowing. In addition to testing the real-time electrogram
morphology recurrence mapping, the study would also like to determine the acute effects of
radiofrequency ablation of areas of high recurrence rates and determine long term freedom
from AF following ablation of areas of high recurrence rates.
Inclusion Criteria:
- Male and female at least 21 years of age
- persistent Afib with one prior failed ablation for persistent or long standing
persistent Afib
Exclusion Criteria:
- Inability to sign consent
- Patients with a life expectancy less than one (1) year
- Patients with chronic kidney disease with sufficiently low GFR that precludes either
CT angiogram of the heart or contrast MRI study
- Pregnant women and women that are breast feeding
- Patients with multiple (2 or more) prior failed ablations
- Patients who have had chemotherapy or radiotherapy within 4 weeks prior to entering
the study or those who have not recovered from adverse events due to agents
administered more than 4 weeks earlier.
We found this trial at
1
site
Miami, Florida 33124
(305) 284-2211
Principal Investigator: Raul Mitrani, MD
Phone: 305-243-5070
University of Miami A private research university with more than 15,000 students from around the...
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