M8891 First in Human in Solid Tumors

Inclusion Criteria:

- Subjects must be refractory to or intolerant of existing cancer therapy(ies) known to
provide clinical benefit.

- Histologically confirmed advanced solid tumors with no clear curative treatment
options available after at least 1 prior systemic anticancer therapy.

- Tumor accessible for biopsies and agreement to conduct pre-dose and post-dose fresh
tumor biopsies.

- Male or female subjects at least 18 years of age.

Exclusion Criteria:

- ECOG PS >= 2

- Extensive prior radiotherapy on more than 30% of bone marrow reserves, or prior bone
marrow/stem cell transplantation within 5 years of study start.

- Severe bone marrow, renal or liver impairment.

- Presence of deep vein thrombosis based on screening lower extremity Doppler
ultrasonography.